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Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.NO through a radical reaction.
It was clarified that imidazolineoxyl N-oxide antagonize EDRF/.NO via a unique radical-radical reaction with .NO. Expand
Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling
  • T. Ida, T. Sawa, +13 authors T. Akaike
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences
  • 14 April 2014
It is proposed that reactive Cys persulfides and S-polythiolation have critical regulatory functions in redox cell signaling and H2S may act primarily as a marker for the biologically active of persulfide species. Expand
Pathogenesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicals.
It is concluded that NO together with O2- which forms more reactive peroxynitrite may be the most important pathogenic factors in influenza virus-induced pneumonia in mice. Expand
Nitric oxide and virus infection
Multiple roles of NO are discussed as related to both non‐specific inflammatory responses and immunological host reactions modulated by NO during infections in vivo, suggesting that viral mutation and evolution may be accelerated by NO‐induced oxidative stress. Expand
Keap1 degradation by autophagy for the maintenance of redox homeostasis
It is found that treatment of cells with tert-butylhydroquinone accelerated the Keap1 degradation and this results indicate that Nrf2 accumulation is the dominant cause to provoke the liver damage in the autophagy-deficient mice. Expand
Nitrated Cyclic GMP Modulates Guard Cell Signaling in Arabidopsis[W]
It is demonstrated that 8-Nitro-cGMP acts as a guard cell signaling molecule and that a NO/8-nitro- cGMP signaling cascade operates in guard cells. Expand
Oxygen radicals in influenza-induced pathogenesis and treatment with pyran polymer-conjugated SOD.
It is indicated that oxygen radicals are important in the pathogenesis of influenza virus infection, and that a polymer-conjugated SOD has therapeutic potential for this virus infection and other diseases associated with free radicals. Expand
Early Phase Tumor Accumulation of Macromolecules: A Great Difference in Clearance Rate between Tumor and Normal Tissues
The results suggest the “EPR effect” in solid tumor primarily arises from in the difference in clearance rate between the solid tumor and the normal tissues after initial penetration of the polymers into these tissues. Expand
Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: implications for the treatment of multiple sclerosis.
Using a combination of immunohistochemistry and reverse transcriptase-dependent in situ polymerase chain reaction analysis, monocytes expressing inducible nitric oxide synthase (iNOS) are identified to be prevalent in the plaque areas of post mortem brain tissue from patients with MS. Expand
Clinical and bacteriological characteristics of Helicobacter cinaedi infection.
The current knowledge and the latest findings relating to H. cinaedi are introduced and it is introduced that a long incubation period is essential for detection in an automatic blood culture system and many of the recent isolates are resistant to both macrolides and quinolones. Expand