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Heparin Cofactor II

Known as: Protease Inhibitor Leuserpin 2, Leuserpin 2, HLS2 
A sulfated plasma protein with a MW of approximately 66kDa that resembles ANTITHROMBIN III. The protein is an inhibitor of thrombin in plasma and is… 
National Institutes of Health

Related topics

Related topics

20 relations

Broader (2)

AntithrombinsSerine Proteinase Inhibitors
Blood coagulationExtracellular SpaceGenes, RegulatorHeparin cofactor II Ag:ACnc:Pt:PPP:Qn

Narrower (1)

Heparin cofactor II deficiency (disorder)

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
The Heparin Binding Properties of Heparin Cofactor II Suggest an Antithrombin-like Activation Mechanism*
The serpin heparin cofactor II (HCII) is a glycosaminoglycan-activated inhibitor of thrombin that circulates at a high… 
Highly Cited
2001
Highly Cited
2001
Role of Lysine 173 in Heparin Binding to Heparin Cofactor 11"
Heparin cofactor I1 (HC) is a plasma serine proteinase inhibitor (serpin) that inhibits a-thrombin in a reaction that is… 
Highly Cited
1999
Highly Cited
1999
Exosites 1 and 2 Are Essential for Protection of Fibrin-bound Thrombin from Heparin-catalyzed Inhibition by Antithrombin and Heparin Cofactor II*
Assembly of ternary thrombin-heparin-fibrin complexes, formed when fibrin binds to exosite 1 on thrombin and fibrin-bound heparin… 
Highly Cited
1990
Highly Cited
1990
On the activation of human leuserpin-2, a thrombin inhibitor, by glycosaminoglycans.
Highly Cited
1989
Highly Cited
1989
Antithrombin activity of fucoidan. The interaction of fucoidan with heparin cofactor II, antithrombin III, and thrombin.
Fucoidan, poly(L-fucopyranose) linked primarily alpha 1----2 with either a C3- or a C4-sulfate, is an effective anticoagulant in… 
Highly Cited
1989
Highly Cited
1989
Anti-thrombin activities of heparin. Effect of saccharide chain length on thrombin inhibition by heparin cofactor II and by antithrombin.
The interactions of two proteinase inhibitors, heparin cofactor II and antithrombin, with thrombin are potentiated by heparin… 
Highly Cited
1988
Highly Cited
1988
Heparin cofactor II: cDNA sequence, chromosome localization, restriction fragment length polymorphism, and expression in Escherichia coli.
Heparin cofactor II (HCII) is an inhibitor of thrombin in plasma that is activated by dermatan sulfate or heparin. An apparently… 
Highly Cited
1987
Highly Cited
1987
Hereditary Heparin Cofactor II Deficiency and the Risk of Development of Thrombosis
Summary Heparin cofactor II (HC II) levels were measured by electroimmunoassay in healthy volunteers, and patients with liver… 
Highly Cited
1986
Highly Cited
1986
Respective role of antithrombin III and heparin cofactor II in the in vitro anticoagulant effect of heparin and of various sulphated polysaccharides
Summary. The in vitro anticoagulant effects of standard heparin (SH) and of seven other sulphated polysaccharides (SPS) were… 
Highly Cited
1985
Highly Cited
1985
Inhibition of chymotrypsin by heparin cofactor II.
Human heparin cofactor II is a plasma protein that is known to inhibit thrombin. The rate of thrombin inhibition by heparin… 
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