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Parenteral anticoagulants: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
TLDR
Three additional parenteral direct thrombin inhibitors and danaparoid are approved as alternatives to heparin in patients with HIT, and fondaparinux-associated HIT or osteoporosis is unlikely to occur.
Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
TLDR
Three addi- tional parenteral direct thrombin inhibitors and danaparoid are approved as alternatives to hep- arin in patients with HIT and fonda- parinux-associated HIT or osteoporosis is unlikely to occur.
Clinical guidelines for testing for heritable thrombophilia
TLDR
All photographs courtesy of Addenbrooke’s Hospital, Cambridge, NIBSC, South Mimms, University of Aberdeen.
Measuring oral direct inhibitors of thrombin and factor Xa: a recommendation from the Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International
TLDR
Oral direct inhibitors of thrombin and factor Xa are now approved as anticoagulant drugs as pharmacokinetic and pharmacodynamic responses are reliably predicted in patients with adequate renal function who are not taking other interacting drugs.
Guidelines on oral anticoagulation with warfarin – fourth edition
TLDR
This guidance is an update of the previous guideline written in 2005 and published in 2006 and replaces the previous BCSH guidelines on oral anticoagulants.
Antiplatelet drugs: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
TLDR
The article describes the mechanisms of action, pharmacokinetics, and pharmacodynamics of aspirin, dipyridamole, cilostazol, the thienopyridines, and the glycoprotein IIb/IIIa antagonists along with a mechanistic overview of results of randomized clinical trials.
Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism
TLDR
The native structure of HCII resembles that of native antithrombin and suggests an alternative mechanism of allosteric activation, whereas the structure of the S195A thrombin–HCII complex defines the molecular basis of allostery.
Acquired hemophilia A in the United Kingdom: a 2-year national surveillance study by the United Kingdom Haemophilia Centre Doctors' Organisation.
TLDR
An observational study to identify and characterize the presenting features and outcome of all patients with acquired hemophilia A in the United Kingdom allowed a consecutive cohort of patients, unbiased by referral or reporting practice, to be studied.
Clinical measurement of thrombin generation by calibrated automated thrombography requires contact factor inhibition
TLDR
CTI can be applied to ETP measurement by CAT and permits the use of CAT in a low TF‐triggered thrombin generation assay without concern for the effect of interference from in‐vitro contact factor activation, and the optimum reagent conditions for using CAT as a global test of coagulability in clinical practice can now be defined.
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