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A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis.
TLDR
An association was found between the presence of the 20210 A allele and elevated prothrombin levels and Elevated pro thirdrombin itself also was found to be a risk factor for venous thrombosis. Expand
Mutation in blood coagulation factor V associated with resistance to activated protein C
TLDR
It is demonstrated that the phenotype of APC resistance is associated with hetero-zygosity or homozygosity for a single point mutation in the factor V gene which predicts the synthesis of a factor V molecule that is not properly inactivated by APC. Expand
A reduced sensitivity for activated protein C in the absence of factor V Leiden increases the risk of venous thrombosis.
TLDR
Results show that a reduced sensitivity for APC, not caused by the factor V Leiden mutation, is a risk factor for venous thrombosis. Expand
Microparticle‐associated tissue factor activity: a link between cancer and thrombosis?
TLDR
An important role is suggested for MP‐associated TF and MUC1 in the pathogenesis of thrombosis in disseminated mucinous adenocarcinoma patients. Expand
Haplotypes of the EPCR gene, plasma sEPCR levels and the risk of deep venous thrombosis
TLDR
The data do not suggest a strong association between EPCR haplotypes and thrombosis risk, but low sEPCR levels appear to reduce the risk of DVT. Expand
High levels of factor IX increase the risk of venous thrombosis.
TLDR
The results show that an elevated level of factor IX is a common risk factor for DVT, and the role of elevated factor IX levels in the development of DVT is investigated. Expand
Genotypic variation in the promoter region of the protein C gene is associated with plasma protein C levels and thrombotic risk.
TLDR
The genotype associated with lower protein C levels (CC/GG/TT genotype) is indeed a risk factor for thrombosis and plasma factor II and factor X levels did not differ between the two groups, which makes a difference in liver function an unlikely cause. Expand
Inherited thrombophilia: Part 1.
TLDR
From the 'Channg Cross and Westminster Medical School London UK IRCCS Maggiore Hospital, Milan Italy, Beth Israel Hospital, Boston USA, and the 'Institute of Thrombosis and Hemostasis Tel Hashomer, Israel. Expand
Pre-analytical and analytical issues in the analysis of blood microparticles.
TLDR
Standardisation of pre-analytical procedures and the introduction of reliable and rapid methods for the measurement of MPs are urgently needed to facilitate their use as biomarker in the pathophysiology of diseases. Expand
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