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Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes.
High levels of procoagulant endothelial microparticles are present in the circulating blood of patients with ACS and may contribute to the generation and perpetuation of intracoronary thrombi.
Membrane microparticles: two sides of the coin.
Microparticles are plasma membrane-derived vesicles shed from stimulated cells, in the broad sense of the term. Their presence is interpreted by proximal or remote cells in fundamental physiological…
Endothelial microparticles in diseases
- G. Chironi, C. Boulanger, A. Simon, F. Dignat-George, J. Freyssinet, A. Tedgui
- MedicineCell and Tissue Research
Improved knowledge of EMP composition, their biological effects, and the mechanisms leading to their clearance will probably open new therapeutic approaches in the treatment of atherothrombosis.
ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine.
Both the efficiency of apoptotic-cell engulfment and the efflux of cellular lipids depend on ABC1-induced perturbation of membrane phosphatidylserine turnover, and it is proposed that transient local exposure of anionic phospholipids in the outer membrane leaflet may be sufficient to alter the general properties of the membrane and thus influence discrete physiological functions.
Elevated levels of circulating procoagulant microparticles in patients with paroxysmal nocturnal hemoglobinuria and aplastic anemia.
It is suggested that shed membrane particles can be considered a valuable biological parameter for the assessment of possible thrombotic complications in patients with PNH.
Shed membrane microparticles with procoagulant potential in human atherosclerotic plaques: a role for apoptosis in plaque thrombogenicity.
- Z. Mallat, B. Hugel, J. Ohan, G. Leséche, J. Freyssinet, A. Tedgui
- 26 January 1999
It is indicated that shed membrane microparticles with procoagulant potential are produced in human atherosclerotic plaques and could be a critical determinant of plaque thrombogenicity after plaque rupture.
Cellular microparticles: what are they bad or good for?
- J. Freyssinet
- Biology, MedicineJournal of thrombosis and haemostasis : JTH
- 1 July 2003
The hemostasis laboratory offers the most appropriate tools for the assessment of the in vivo significance of microparticles, since they are thought to reflect a balance between cell stimulation, proliferation, and death and it is conceivable that they are discerned as sensors for the maintenance of homeostasis in multicellular organisms.
The significance of shed membrane particles during programmed cell death in vitro, and in vivo, in HIV-1 infection.
- K. Aupeix, B. Hugel, +4 authors J. Freyssinet
- Biology, MedicineThe Journal of clinical investigation
- 1 April 1997
A clear correlation between the degree of apoptosis induced by a variety of agents in several types of cultured cells and the amount of shed membrane microparticles captured in the corresponding supernatants by insolubilized annexin V, a protein showing a strong affinity for phosphatidylserine is reported.
Increased levels of circulating microparticles in primary Sjögren's syndrome, systemic lupus erythematosus and rheumatoid arthritis and relation with disease activity
Plasma MP level is elevated in primary Sjögren's syndrome, as well as in SLE and RA, and could be used as a biomarker reflecting systemic cell activation, and increase of platelet-derived MPs, sCD40L and sCD62P, highlights platelet activation in pSS.
Microparticles: a critical component in the nexus between inflammation, immunity, and thrombosis
- O. Morel, N. Morel, L. Jesel, J. Freyssinet, F. Toti
- Biology, MedicineSeminars in Immunopathology
- 25 August 2011
Owing to their ability to cargo bioactive signals, MPs could be viewed as an integrated communication network enabling the coordination of complex cellular responses in biological fluids and the maintenance of the homeostasis equation.