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Development of the human coagulation system in the full-term infant.
TLDR
A large cohort of infants studied consecutively in the postnatal period allowed us to determine the normal development of the human coagulation system in the full-term infant and found that near-adult values are achieved for most components by 6 months of life.
Structure and Anticoagulant Activity of a Fucosylated Chondroitin Sulfate from Echinoderm
TLDR
Assays with purified reagents show that the fucosylated chondroitin sulfate can potentiate the thrombin inhibition activity of both antithrombin and heparin cofactor II.
Development of the human coagulation system in the healthy premature infant
TLDR
The postnatal maturation towards adult levels was accelerated in premature infants as compared with the fullterm infants and with adults.
Highly Sulfated Dermatan Sulfates from Ascidians
TLDR
These naturally oversulfated ascidian dermatan sulfates are sulfated at selected sites required for interaction with heparin cofactor II and thus have specific and potent anticoagulant activity.
Development of the human coagulation system in the healthy premature infant.
TLDR
The postnatal maturation towards adult levels was accelerated in premature infants as compared with the fullterm infants and with adults.
A Unique Dermatan Sulfate-like Glycosaminoglycan from Ascidian:
TLDR
Results suggest that 4-O-sulfation of the N-acetyl-β-D-galactosamine residues is essential for the anticoagulant activity of dermatan sulfate.
Selective cleavage and anticoagulant activity of a sulfated fucan: stereospecific removal of a 2-sulfate ester from the polysaccharide by mild acid hydrolysis, preparation of oligosaccharides, and
TLDR
The low-molecular-weight derivatives obtained from the sulfated fucan were employed to determine the requirement for interaction of this polysaccharide with heparin cofactor II and to achieve complete thrombin inhibition.
Heparin cofactor II modulates the response to vascular injury.
  • D. Tollefsen
  • Biology
    Arteriosclerosis, thrombosis, and vascular…
  • 1 March 2007
TLDR
Studies with HCII knockout mice directly support the hypothesis that HCII interacts with dermatan sulfate in the arterial wall after endothelial injury and thereby exerts an antithrombotic effect and suggest thatHCII plays a unique and important role in vascular homeostasis.
Activation of heparin cofactor II by dermatan sulfate.
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