Half Maximal Inhibitory Concentration Subject Result Measurement

Known as: IC50 Subject Result, IC50 Treatment Result, IC50S 
A measurement of titer of a viral organism or biological/biochemical reaction that has been exposed to a concentration of a specific drug expected to… (More)
National Institutes of Health

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Clinical Data Interchange Standards Consortium TerminologyInhibitory Concentration 50

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Highly Cited
2008
Highly Cited
2008
Determinants of in vitro drug susceptibility testing of Plasmodium vivax.
In Papua, Indonesia, the antimalarial susceptibility of Plasmodium vivax (n = 216) and P. falciparum (n = 277) was assessed using… (More)
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Highly Cited
2007
Highly Cited
2007
High-throughput Plasmodium falciparum growth assay for malaria drug discovery.
New therapeutic agents for the treatment of malaria, the world's most deadly parasitic disease, are urgently needed. Malaria… (More)
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Highly Cited
2006
Highly Cited
2006
Novel gyrase mutations in quinolone-resistant and -hypersusceptible clinical isolates of Mycobacterium tuberculosis: functional analysis of mutant enzymes.
Mutations in the DNA gyrase GyrA2GyrB2 complex are associated with resistance to quinolones in Mycobacterium tuberculosis. As… (More)
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Highly Cited
2005
Highly Cited
2005
Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6.
Artemisinin derivatives are an essential component of treatment against multidrug-resistant Plasmodium falciparum malaria. We… (More)
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Highly Cited
2003
Highly Cited
2003
The effects of vinflunine, vinorelbine, and vinblastine on centromere dynamics.
Vinflunine is a novel fluorinated Vinca alkaloid currently in Phase II clinical trials, which in preclinical studies exhibited… (More)
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Highly Cited
2002
Highly Cited
2002
Celecoxib exhibits the greatest potency amongst cyclooxygenase (COX) inhibitors for growth inhibition of COX-2-negative hematopoietic and epithelial cell lines.
Cyclooxygenase-2 (COX-2) is an important cellular target for both therapy and/or prevention of inflammatory disorders and cancer… (More)
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Highly Cited
1999
Highly Cited
1999
P-glycoprotein and cytochrome P-450 3A inhibition: dissociation of inhibitory potencies.
Many P-glycoprotein (P-gp) inhibitors studied in vitro and in vivo are also known or suspected to be substrates and/or inhibitors… (More)
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Highly Cited
1998
Highly Cited
1998
Cytotoxicity evaluation of 43 metal salts using murine fibroblasts and osteoblastic cells.
Metallic biomaterials are generally used for replacement of structural components of the human body such as bones, joints, and… (More)
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Highly Cited
1996
Highly Cited
1996
Inotropic effects of propofol, thiopental, midazolam, etomidate, and ketamine on isolated human atrial muscle.
BACKGROUND Cardiovascular instability after intravenous induction of anesthesia may be explained partly by direct negative… (More)
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Highly Cited
1987
Highly Cited
1987
The novel anticonvulsant MK-801 binds to the activated state of the N-methyl-D-aspartate receptor in rat brain.
The influence of endogenous and exogenous acidic amino acids on the binding of [3H]-MK-801, a selective, non-competitive… (More)
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