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Half Maximal Inhibitory Concentration Subject Result Measurement

Known as: IC50 Subject Result, IC50 Treatment Result, IC50S 
A measurement of titer of a viral organism or biological/biochemical reaction that has been exposed to a concentration of a specific drug expected to… 
National Institutes of Health

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Related topics

3 relations
CDISC SDTM Microbiology Susceptibility Test Name TerminologyClinical Data Interchange Standards Consortium TerminologyInhibitory Concentration 50

Papers overview

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Highly Cited
2003
Highly Cited
2003
Apoptosis induction and enhancement of cytotoxicity of anticancer drugs by celecoxib, a selective cyclooxygenase-2 inhibitor, in human head and neck carcinoma cell lines.
Colorectal carcinomas are well known to highly express COX-2 and their growth is markedly inhibited by COX-2 inhibitors, but… 
2001
2001
Inhibition of growth of human breast carcinoma cells by an antisense oligonucleotide targeted to the transferrin receptor gene.
Transferrin receptor expression is controlled by the amount of iron required by the cell to maintain its metabolism and therefore… 
2001
2001
Levobetaxolol (Betaxon) and other beta-adrenergic antagonists: preclinical pharmacology, IOP-lowering activity and sites of action in human eyes.
The pharmacological characteristics of levobetaxolol, a single active isomer of betaxolol, were determined and compared with… 
Highly Cited
1999
Highly Cited
1999
Comparison of antagonist potencies at pre‐ and post‐synaptic GABAB receptors at inhibitory synapses in the CA1 region of the rat hippocampus
Synaptic activation of γ‐aminobutyric acid (GABA)B receptors at GABA synapses causes (a) postsynaptic hyperpolarization mediating… 
Highly Cited
1999
Highly Cited
1999
Enhanced Inhibition of Human Anti-Gal Antibody Binding to Mammalian Cells by Synthetic α-Gal Epitope Polymers
Neoglycopolymers of polyacrylamide backbone conjugated with varying densities of Galα1−3Galβ1−4Glcβ trisaccharide epitopes (α-Gal… 
Highly Cited
1998
Highly Cited
1998
DNA-Directed alkylating agents. 7. Synthesis, DNA interaction, and antitumor activity of bis(hydroxymethyl)- and bis(carbamate)-substituted pyrrolizines and imidazoles.
A series of bis(hydroxymethyl)-substituted imidazoles, thioimidazoles, and pyrrolizines and related bis(carbamates), linked to… 
Highly Cited
1995
Highly Cited
1995
Tyrosine kinase inhibitors. 4. Structure-activity relationships among N- and 3-substituted 2,2'-dithiobis(1H-indoles) for in vitro inhibition of receptor and nonreceptor protein tyrosine kinases.
A series of 3-substituted 2,2'-dithiobis(1H-indoles) were synthesized and evaluated for their ability to inhibit the tyrosine… 
Highly Cited
1994
Highly Cited
1994
Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities.
Classical antifolate analogues containing a novel furo[2,3-d]pyrimidine ring system which include N-[4-[N-[(2,4-diaminofuro[2,3-d… 
Highly Cited
1990
Highly Cited
1990
DNA-directed alkylating agents. 1. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the reactivity of the mustard.
A series of DNA-targeted aniline mustards have been prepared, and their chemical reactivity and in vitro and in vivo cytotoxicity… 
1990
1990
Trans n-3 eicosapentaenoic and docosahexaenoic acid isomers exhibit different inhibitory effects on arachidonic acid metabolism in human platelets compared to the respective cis fatty acids.
N-3 trans geometrical isomers of 20:5 n-3 and 22:6 n-3 were isolated from rats fed heated linseed oil. The ability of these acids… 
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