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Half Maximal Inhibitory Concentration Subject Result Measurement

Known as: IC50 Subject Result, IC50 Treatment Result, IC50S 
A measurement of titer of a viral organism or biological/biochemical reaction that has been exposed to a concentration of a specific drug expected to… 
National Institutes of Health

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Related topics

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CDISC SDTM Microbiology Susceptibility Test Name TerminologyClinical Data Interchange Standards Consortium TerminologyInhibitory Concentration 50

Papers overview

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2017
2017
Abstract 5: The effects of SIRT1 inhibitors nicotinamide and Ex-527 on lymphoma cells
SIRT1 is a well-known lysine-deacetylase, having both histone and non-histone proteins as molecular targets. SIRT1 may function… 
2012
2012
Design, synthesis, and cytotoxic activities of new 2,4,5-triarylimidazoles
A new group of 2,4,5-triarylimidazoles containing N,N-dimethylaminoethoxy or piperidinyl ethoxy group at the para position of the… 
2011
2011
Partial purification of crude stem bromelain improves it sensitivity as a protease inhibitive assay for heavy metals
The protease inhibitive assay for heavy metals is a novel and robust detection method suitable for preliminary screening method… 
Review
2011
Review
2011
Chemical and Biological Profile of Dual Cdk 1 and Cdk 2 Inhibitors
The importance of Cdks in cell cycle regulation, their interaction with oncogenes and tumor suppressors, and their frequent… 
2010
2010
Activity of novel RET inhibitors against RET genotypes associated with medullary thyroid cancer.
5559 Background: Point mutations in RET tyrosine kinase, most commonly C634R and M918T, result in the development of medullary… 
2010
2010
Abstract P6-15-17: Synergy of Ixabepilone and Dasatinib in Triple Negative Breast Cancer Cell Lines
Background: Treatment options are very limited for breast cancers that do not express HER2 or estrogen and progesterone receptors… 
Review
2010
Review
2010
TARGETING ANGIOPOIETIN-2 INHIBITS ANGIOGENESIS , TIE 2 EXPRESSING MONOCYTE INFILTRATION AND TUMOR GROWTH
Purpose: Angiopoietin-1 (Ang1) plays a key role in maintaining stable vasculature, while in tumor Ang2 antagonizes Ang1’s… 
2008
2008
Preclinical evaluation of sunitinib, alone and in combination with trastuzumab, in HER2 positive breast cancer (BC)
14689 Background: There is a potentially therapeutically relevant interaction between the HER2 and VEGF systems. In addition to… 
1995
1995
Relationship between pharmacokinetic parameters in patients and cytotoxicity in vitro of standard and investigational anticancer drugs
The selection of the starting dose for initial clinical trials of anticancer agents is mostly determined by toxicological… 
Highly Cited
1990
Highly Cited
1990
DNA-directed alkylating agents. 1. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the reactivity of the mustard.
A series of DNA-targeted aniline mustards have been prepared, and their chemical reactivity and in vitro and in vivo cytotoxicity…