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Inhibitory Concentration 50

Known as: Concentration 50, Inhibitory, IC50, inhibitory concentration 50% (IC50) 
The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed… Expand
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
The Bcr-Abl tyrosine kinase oncogene causes chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute… Expand
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Highly Cited
2002
Highly Cited
2002
Small molecule inhibitors have proven extremely useful for investigating signal transduction pathways and have the potential for… Expand
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Highly Cited
1999
Highly Cited
1999
TLR4 is a member of the recently identified Toll-like receptor family of proteins and has been putatively identified as Lps, the… Expand
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Highly Cited
1995
Highly Cited
1995
PD 098059 has been shown previously to inhibit the dephosphorylated form of mitogen-activated protein kinase kinase-1 (MAPKK1… Expand
Highly Cited
1995
Highly Cited
1995
A class of pyridinyl imidazoles inhibit the MAP kinase homologue, termed here reactivating kinase (RK) [Lee et al. (1994) Nature… Expand
Highly Cited
1995
Highly Cited
1995
  • L. Gallo
  • GWUMC Department of Biochemistry Annual Spring…
  • 1995
  • Corpus ID: 546674
Shaker A. Mousa and Thomas M. Reilly The DuPont Merck Pharmaceutical Company Cardiovascular Diseases Div., Exp. Station… Expand
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Highly Cited
1994
Highly Cited
1994
Phosphatidylinositol (PtdIns) 3-kinase is an enzyme implicated in growth factor signal transduction by associating with receptor… Expand
Highly Cited
1993
Highly Cited
1993
Constitutive cyclooxygenase (COX-1; prostaglandin-endoperoxide synthase, EC 1.14.99.1) is present in cells under physiological… Expand
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Highly Cited
1991
Highly Cited
1991
Staurosporine is the most potent inhibitor of protein kinase C (PKC) described in the literature with a half-maximal inhibitory… Expand
Highly Cited
1986
Highly Cited
1986
Staurosporine, microbial alkaloid which has been known to have antifungal activity was found to inhibit markedly phospholipid/Ca… Expand