Inhibitory Concentration 50
Semantic Scholar uses AI to extract papers important to this topic.
The Bcr-Abl tyrosine kinase oncogene causes chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute… Expand Small molecule inhibitors have proven extremely useful for investigating signal transduction pathways and have the potential for… Expand TLR4 is a member of the recently identified Toll-like receptor family of proteins and has been putatively identified as Lps, the… Expand PD 098059 has been shown previously to inhibit the dephosphorylated form of mitogen-activated protein kinase kinase-1 (MAPKK1… Expand A class of pyridinyl imidazoles inhibit the MAP kinase homologue, termed here reactivating kinase (RK) [Lee et al. (1994) Nature… Expand Shaker A. Mousa and Thomas M. Reilly The DuPont Merck Pharmaceutical Company Cardiovascular Diseases Div., Exp. Station… Expand Phosphatidylinositol (PtdIns) 3-kinase is an enzyme implicated in growth factor signal transduction by associating with receptor… Expand Constitutive cyclooxygenase (COX-1; prostaglandin-endoperoxide synthase, EC 22.214.171.124) is present in cells under physiological… Expand Staurosporine is the most potent inhibitor of protein kinase C (PKC) described in the literature with a half-maximal inhibitory… Expand Staurosporine, microbial alkaloid which has been known to have antifungal activity was found to inhibit markedly phospholipid/Ca… Expand