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- Publications
- Influence
GABAB-receptor subtypes assemble into functional heteromeric complexes
- K. Kaupmann, B. Malitschek, +9 authors B. Bettler
- Biology, Medicine
- Nature
- 17 December 1998
B-type receptors for the neurotransmitter GABA (γ-aminobutyric acid) inhibit neuronal activity through G-protein-coupled second-messenger systems, which regulate the release of neurotransmitters and… Expand
Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.
- K. Kaupmann, K. Huggel, +8 authors B. Bettler
- Medicine
- Nature
- 1997
GABA (gamma-amino-butyric acid), the principal inhibitory neurotransmitter in the brain, signals through ionotropic (GABA(A)/ GABA(c)) and metabotropic (GABA(B)) receptor systems. Here we report the… Expand
Expression cloning of GABAB receptors uncovers similarity to metabotropic glutamate receptors
- K. Kaupmann, K. Huggel, +8 authors B. Bettler
- Biology
- Nature
- 20 March 1997
GABA (γ-amino-butyric acid), the principal inhibitory neurotransmitter in the brain, signals through ionotropic (GABAA/GABAC) and metabotropic (GABAB) receptor systems. Here we report the cloning of… Expand
Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501.
- S. Urwyler, J. Mosbacher, +5 authors K. Kaupmann
- Chemistry, Medicine
- Molecular pharmacology
- 1 November 2001
The compounds CGP7930 [2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol] and its close analog CGP13501 were identified as positive modulators of gamma-aminobutyric acid(B) (GABA(B))… Expand
International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyric acid(B) receptors: structure and function.
- N. Bowery, B. Bettler, +5 authors S. J. Enna
- Medicine
- Pharmacological reviews
- 2002
The gamma-aminobutyric acid(B) (GABA(B)) receptor was first demonstrated on presynaptic terminals where it serves as an autoreceptor and also as a heteroreceptor to influence transmitter release by… Expand
Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels.
- K. Kaupmann, V. Schuler, +8 authors B. Bettler
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 8 December 1998
gamma-Aminobutyric acid type B receptors (GABABRs) are involved in the fine tuning of inhibitory synaptic transmission. Presynaptic GABABRs inhibit neurotransmitter release by down-regulating… Expand
Mutagenesis and Modeling of the GABAB Receptor Extracellular Domain Support a Venus Flytrap Mechanism for Ligand Binding*
- T. Galvez, M. Parmentier, +7 authors J. Pin
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 7 May 1999
The γ-aminobutyric acid type B (GABAB) receptor is distantly related to the metabotropic glutamate receptor-like family of G-protein-coupled receptors (family 3). Sequence comparison revealed that,… Expand
CGP 35348: a centrally active blocker of GABAB receptors.
- H. R. Olpe, G. Karlsson, +7 authors H. Bittiger
- Biology, Medicine
- European journal of pharmacology
- 2 October 1990
The biochemical, electrophysiological and pharmacological properties of the new GABAB receptor blocker CGP 35348 are described. In a variety of receptor binding assays CGP 35348 showed affinity for… Expand
Epilepsy, Hyperalgesia, Impaired Memory, and Loss of Pre- and Postsynaptic GABAB Responses in Mice Lacking GABAB(1)
- V. Schuler, C. Lüscher, +21 authors B. Bettler
- Biology, Medicine
- Neuron
- 19 July 2001
GABA(B) (gamma-aminobutyric acid type B) receptors are important for keeping neuronal excitability under control. Cloned GABA(B) receptors do not show the expected pharmacological diversity of native… Expand
C-Terminal Interaction Is Essential for Surface Trafficking But Not for Heteromeric Assembly of GABAB Receptors
- A. Pagano, G. Rovelli, +16 authors B. Bettler
- Chemistry, Medicine
- The Journal of Neuroscience
- 15 February 2001
Assembly of fully functional GABAB receptors requires heteromerization of the GABAB(1) and GABAB(2)subunits. It is thought that GABAB(1) and GABAB(2) undergo coiled-coil dimerization in their… Expand