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Pharmacological characterization of [3H]‐prostaglandin E2 binding to the cloned human EP4 prostanoid receptor
Prostaglandin (PG) E2 (PGE2) is a potent prostanoid derived from arachidonic which can interact with EP1, EP2, EP3 and EP4 prostanoid receptor subtypes. Recombinant human EP4 receptors expressed inExpand
Pharmacological characterization of [(3)H]-prostaglandin E(2) binding to the cloned human EP(4) prostanoid receptor.
Recombinant human EP(4) receptors expressed in human embryonic kidney (HEK-293) cells were evaluated for their binding characteristics using [(3)H]-PGE(2) and a broad panel of natural and synthetic prostanoids in order to define their pharmacological properties. Expand
Effect of Administration of Oxytocin During Diestrus on Corpus Luteum Function and Endometrial Oxytocin Receptor Concentration in Cycling Mares
There was no significant difference in the proportion of mares with prolonged CL function between the two oxytocin-treated groups, and collectively, oxytoc in treatment increased between control and oxytocIn-treated mares. Expand
Pharmacology of [3H]prostaglandin E1/[3H]prostaglandin E2 and [3H]prostaglandin F2alpha binding to EP3 and FP prostaglandin receptor binding sites in bovine corpus luteum: characterization and
These studies have provided strong pharmacological evidence for the similarity of [3H]PGE1 and [3 h)PGE2 binding to EP3 receptors and for [3h]PGF2alpha binding to FP receptors in washed bovine corpus luteum homogenates. Expand
Progesterone Inhibits Oxytocin- and Prostaglandin F2alpha-Stimulated Increases in Intracellular Calcium Concentrations in Small and Large Ovine Luteal Cells1
Abstract There is increasing evidence that the corpus luteum has an important role in regulating its own demise. A series of experiments was performed to study the effects of luteal concentrations ofExpand
Judge, jury and executioner: the auto-regulation of luteal function.
It was concluded that normal luteal concentrations of progesterone prevent the oxytocin and perhaps the PGF2alpha-induced increase in the number of small and large lutesal cells which respond to these hormones with increased intracellular concentrations of calcium. Expand
Insight into the neuroendocrine site and cellular mechanism by which cortisol suppresses pituitary responsiveness to gonadotropin-releasing hormone.
Evidence is provided that cortisol acts via the type II GR within the pituitary gland to elicit a rapid decrease in responsiveness to GnRH, independent of changes in expression of the GnRH receptor. Expand
Effects of bradykinin on signal transduction, cell proliferation, and cytokine, prostaglandin E2 and collagenase‐1 release from human corneal epithelial cells
The functional coupling of the BK receptors to various physiological and pathological mechanisms in the CEPI cells, including phosphoinositide (PI) turnover, intracellular Ca2+‐mobilization ([Ca2+]i), cell proliferation, and the release of various cytokines, collagenase‐1 (matrix metalloproteinase‐ 1) and prostaglandin E2 (PGE2) are studied. Expand
Levobetaxolol (Betaxon) and other beta-adrenergic antagonists: preclinical pharmacology, IOP-lowering activity and sites of action in human eyes.
Levobetaxolol is a potent, high affinity and beta1-selective IOP-lowering beta-adrenoceptor antagonist. Expand
Peripheral-type benzodiazepine receptor (PBR) aggregation and absence of steroidogenic acute regulatory protein (StAR)/PBR association in the mitochondrial membrane as determined by bioluminescence
Data was obtained indicating that PBR forms aggregates in the mitochondrial membrane, however there was no evidence that P BR aggregation is regulated in the acute control of steroidogenesis, or that StAR and StAR interact. Expand