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HP protein, human

Known as: Ainp2 protein, human, HP, haptoglobin, human 
Haptoglobin (406 aa, ~45 kDa) is encoded by the human HP gene. This protein plays a role in tight junction disassembly, intestinal permeability, heme… 
National Institutes of Health

Related topics

Related topics

5 relations
HP geneLigand BindingMolecular TransportSushi Domain

Broader (1)

Haptoglobins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Gut Microbiota, Microinflammation, Metabolic Profile, and Zonulin Concentration in Obese and Normal Weight Subjects
The association between gut microbiota and circulating zonulin level, a marker of intestinal permeability, has not been studied… 
Highly Cited
2010
Highly Cited
2010
Restoration of impaired intestinal barrier function by the hydrolysed casein diet contributes to the prevention of type 1 diabetes in the diabetes-prone BioBreeding rat
Aims/hypothesisImpaired intestinal barrier function is observed in type 1 diabetes patients and animal models of the disease… 
Highly Cited
2009
Highly Cited
2009
Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2
Increased intestinal permeability (IP) has emerged recently as a common underlying mechanism in the pathogenesis of allergic… 
Review
2008
Review
2008
Autoantibodies in celiac disease
Autoantibody production is an important feature of many autoimmune disorders, signifying a breakdown of immune tolerance to self… 
Highly Cited
2006
Highly Cited
2006
Gliadin Stimulation of Murine Macrophage Inflammatory Gene Expression and Intestinal Permeability Are MyD88-Dependent: Role of the Innate Immune Response in Celiac Disease1
Recent studies have demonstrated the importance of TLR signaling in intestinal homeostasis. Celiac disease (CD) is an autoimmune… 
Highly Cited
2006
Highly Cited
2006
VSL#3 probiotic preparation has the capacity to hydrolyze gliadin polypeptides responsible for Celiac Sprue.
Highly Cited
2005
Highly Cited
2005
Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats.
Increased intestinal permeability has been observed in numerous human autoimmune diseases, including type-1 diabetes (T1D) and… 
Highly Cited
2003
Highly Cited
2003
Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function
Background and aims: Despite the progress made in understanding the immunological aspects of the pathogenesis of coeliac disease… 
Highly Cited
2001
Highly Cited
2001
Zonula Occludens Toxin Structure-Function Analysis
Zonula occludens toxin (Zot) is an enterotoxin elaborated by Vibrio cholerae that increases intestinal permeability by… 
Review
2000
Review
2000
Regulation of Intercellular Tight Junctions by Zonula Occludens Toxin and Its Eukaryotic Analogue Zonulin
Abstract: The intestinal epithelium represents the largest interface between the external environment and the internal host… 
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