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Spectrum of gluten-related disorders: consensus on new nomenclature and classification
This review will summarize the current knowledge about the three main forms of gluten reactions: allergic (wheat allergy), autoimmune (celiac disease, dermatitis herpetiformis and gluten ataxia) and possibly immune-mediated (gluten sensitivity), and also outline pathogenic, clinical and epidemiological differences and propose new nomenclature and classifications.
Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity
This study shows that the two gluten-associated disorders, CD and GS, are different clinical entities, and it contributes to the characterization of GS as a condition associated with prevalent gluten-induced activation of innate, rather than adaptive, immune responses in the absence of detectable changes in mucosal barrier function.
Non-Celiac Gluten Sensitivity: The New Frontier of Gluten Related Disorders
The major advances and current trends on Non Celiac Gluten sensitivity are reported, including an overlap between the irritable bowel syndrome (IBS) and NCGS has been detected, requiring even more stringent diagnostic criteria.
Zonulin Upregulation Is Associated With Increased Gut Permeability in Subjects With Type 1 Diabetes and Their Relatives
Zonulin upregulation seems to precede the onset of the disease, providing a possible link between increased intestinal permeability, environmental exposure to non–self antigens, and the development of autoimmunity in genetically susceptible individuals.
Characterization of the human dihydropyrimidine dehydrogenase gene.
These studies have established that the DPYD gene is unusually large, and lay a framework for uncovering new mutations that are responsible for thymine-uraciluria and toxicity to fluoropyrimidine drugs.
Celiac disease: a comprehensive current review
The present review is timely and provides a thorough appraisal of various aspects characterizing celiac disease, and the identification of alternative or complementary treatments to the gluten-free diet brings hope for patients unavoidably burdened by diet restrictions.
The Overlapping Area of Non-Celiac Gluten Sensitivity (NCGS) and Wheat-Sensitive Irritable Bowel Syndrome (IBS): An Update
Clinicians are provided with an update that directly impacts on the management of a subgroup of their IBS patients whose symptoms are triggered by wheat ingestion.
Alterations of the Intestinal Barrier in Patients With Autism Spectrum Disorders and in Their First-degree Relatives
- L. de Magistris, V. Familiari, C. Bravaccio
- MedicineJournal of pediatric gastroenterology and…
- 1 October 2010
It is indicated that measuring IPT could help to identify a subgroup of patients with autism who could benefit from a gluten-free diet and indicate the presence of an intestinal (tight-junction linked) hereditary factor in the families of subjects with autism.
Blood–brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders
In the ASD brain, there is an altered expression of genes associated with BBB integrity coupled with increased neuroinflammation and possibly impaired gut barrier integrity, which seems to be specific for ASD.
Differential Mucosal IL-17 Expression in Two Gliadin-Induced Disorders: Gluten Sensitivity and the Autoimmune Enteropathy Celiac Disease
- A. Sapone, K. Lammers, A. Fasano
- Medicine, BiologyInternational Archives of Allergy and Immunology
- 24 November 2009
It is concluded that GS, albeit gluten-induced, is different from CD not only with respect to the genetic makeup and clinical and functional parameters, but also withrespect to the nature of the immune response.