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HOE-498

Known as: HOE 498, HOE498 
National Institutes of Health

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1 relation

Broader (1)

Ramipril

Papers overview

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1988
1988
Comparison of the effects of the dipeptidyl peptidase inhibitors captopril, ramipril, and enalapril on water intake and sodium appetite of Sprague-Dawley rats.
Two experiments were performed with Sprague-Dawley rats to study the effects of different inhibitors of angiotensin I converting… 
1987
1987
Pharmacokinetics of ramipril in the elderly.
Highly Cited
1986
Highly Cited
1986
Reduction of reperfusion arrhythmias in the ischemic isolated rat heart by angiotensin converting enzyme inhibitors: a comparison of captopril, enalapril, and HOE 498.
The effects of the angiotensin converting enzyme (ACE) inhibitors captopril, enalapril, HOE 498, and its prodrug on reperfusion… 
Highly Cited
1986
Highly Cited
1986
Antihypertensive Action of the Converting Enzyme Inhibitor Perindopril (S9490-3) in Spontaneously Hypertensive Rats: Comparison with Enalapril (MK421) and Ramipril (HOE498)
Summary: The novel prodrug-converting-enzyme (CE) inhibitor perindopril (S9490-3) diacid was found to be as potent as ramipril… 
1986
1986
Converting enzyme inhibitors and brain angiotensin.
The spontaneously hypertensive rat (SHR) has many characteristics indicative of an overactive brain-angiotensin system. Since… 
Highly Cited
1985
Highly Cited
1985
Persistent Tissue Converting Enzyme Inhibition Following Chronic Treatment with Hoe498 and MK421 in Spontaneously Hypertensive Rats
Inhibition of angiotensin II generation in the plasma does not fully explain the antihypertensive effects of converting enzyme… 
1985
1985
Synthesis of a highly active angiotensin converting enzyme inhibitor: 2-[N-[(S)-1-ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-(1S,3S,5S)-2- azabicyclo[3.3.0]octane-3-carboxylic acid (Hoe 498).
The convergent, diastereoselective synthesis of 2-[N-[(S)-1-ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-(1S,3S,5S)-2- azabicyclo[3.3… 
Highly Cited
1984
Highly Cited
1984
Is Tissue Converting Enzyme Inhibition a Determinant of the Antihypertensive Efficacy of Converting Enzyme Inhibitors? Studies with the Two Different Compounds, Hoe498 and MK421, in Spontaneously…
The mechanism of antihypertensive action of converting enzyme (CE) inhibitors was studied by comparing two compounds of different… 
1984
1984
Pharmacokinetics and biotransformation of 2-[N-[(S)-1-ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-(1S,3S, 5S)-2-azabicyclo [3.3.0]octane-3-carboxylic acid (Hoe 498) in rat, dog and man.
After oral administration, 2 mg/kg in rat and dog, 10 mg in man, of the carbon-14-labeled angiotensin I converting enzyme… 
1984
1984
Cardiovascular and antihypertensive activities of the novel non-sulfhydryl converting enzyme inhibitor 2-[N-[(S)-1-ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-(1S,3S,5S)-2- azabicyclo[3.3.0]octane-3…
The cardiovascular and antihypertensive activities of the novel orally active non-sulfhydryl converting enzyme (CE) inhibitor 2… 
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