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HMGCR protein, human

Known as: 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase, 3-hydroxy-3-methylglutaryl-CoA reductase, human, HMG-CoA Reductase 
3-hydroxy-3-methylglutaryl-coenzyme A reductase (888 aa, ~97 kDa) is encoded by the human HMGCR gene. This protein is involved in cholesterol… 
National Institutes of Health

Related topics

Related topics

14 relations
Atorvastatin SodiumAtorvastatin calciumCholesterol HomeostasisEnzyme Gene

Broader (2)

Hydroxymethylglutaryl coenzyme A reductaseHydroxymethylglutaryl-CoA reductase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Low LDL cholesterol, PCSK9 and HMGCR genetic variation, and risk of Alzheimer’s disease and Parkinson’s disease: Mendelian randomisation study
ObjeCtive To test the hypothesis that low density lipoprotein (LDL) cholesterol due to genetic variation in the genes responsible… 
Highly Cited
2017
Highly Cited
2017
Low LDL cholesterol, PCSK9 and HMGCR genetic variation, and risk of Alzheimer’s disease and Parkinson’s disease: Mendelian randomisation study
Objective To test the hypothesis that low density lipoprotein (LDL) cholesterol due to genetic variation in the genes responsible… 
Review
2016
Review
2016
Anti-HMGCR antibodies as a biomarker for immune-mediated necrotizing myopathies: A history of statins and experience from a large international multi-center study.
Highly Cited
2016
Highly Cited
2016
Cancer association as a risk factor for anti-HMGCR antibody-positive myopathy
Objective: To show cancer association is a risk factor other than statin exposure for anti-3-hydroxy-3-methylglutaryl coenzyme A… 
Highly Cited
2015
Highly Cited
2015
MicroRNA-195 inhibits proliferation, invasion and metastasis in breast cancer cells by targeting FASN, HMGCR, ACACA and CYP27B1
De novo lipogenesis, a hallmark for cancers is required for cellular transformation. Further it is believed that resistance to… 
Highly Cited
2015
Highly Cited
2015
Peptides from cowpea present antioxidant activity, inhibit cholesterol synthesis and its solubilisation into micelles.
Highly Cited
2011
Highly Cited
2011
Rutin inhibits oleic acid induced lipid accumulation via reducing lipogenesis and oxidative stress in hepatocarcinoma cells.
Excessive lipid accumulation within liver has been proposed to cause obesity, hyperlipidemia, diabetes, and fatty liver disease… 
Review
2009
Review
2009
The role of HMGCR alternative splicing in statin efficacy.
Highly Cited
2008
Highly Cited
2008
Common SNPs in HMGCR in Micronesians and Whites Associated With LDL-Cholesterol Levels Affect Alternative Splicing of Exon13
Background—Variation in LDL-cholesterol (LDL-C) among individuals is a complex genetic trait involving multiple genes and gene… 
Highly Cited
1975
Highly Cited
1975
Sterol balance studies in the rat. Effects of dietary cholesterol and beta-sitosterol on sterol balance and rate-limiting enzymes of sterol metabolism.
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