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ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.
TLDR
The apoE-deficient mouse contains the entire spectrum of lesions observed during atherogenesis and is the first mouse model to develop lesions similar to those in humans. Expand
Low-density lipoprotein subclass patterns and risk of myocardial infarction.
TLDR
The association of low-density lipoprotein (LDL) subclass patterns with coronary heart disease was investigated in a case-control study of nonfatal myocardial infarction and multivariate logistic regression analyses showed that both high-density cholesterol and triglyceride levels contributed to the risk associated with the small, dense LDL subclass pattern. Expand
Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
TLDR
apoE-deficient mice are a promising small animal model to help understand the role of apoE in vivo and the genetic and environmental determinants of atherosclerosis. Expand
Whole population, genome-wide mapping of hidden relatedness.
TLDR
This work uses GERMLINE, a robust algorithm for identifying segmental sharing indicative of recent common ancestry between pairs of individuals, to comprehensively survey hidden relatedness both in the HapMap as well as in a densely typed island population of 3000 individuals. Expand
Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction.
TLDR
The inverse association of moderate alcohol intake with the risk of myocardial infarction is confirmed and support the view that the effect is mediated, in large part, by increases in both HDL2 and HDL3. Expand
Hepatocyte nuclear factor-1α is an essential regulator of bile acid and plasma cholesterol metabolism
TLDR
It is demonstrated that Tcf1, in addition to being an important regulator of insulin secretion, is an essential transcriptional regulator of bile acid and HDL-cholesterol metabolism. Expand
Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype.
TLDR
Results indicate that overexpression of Pcsk9 interferes with LDLR-mediated LDL cholesterol uptake and may be involved in a novel mechanism to modulate LDLR function by an alternative pathway than classic cholesterol inhibition of sterol regulatory element binding protein-mediated transcription. Expand
Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mices⃞s⃞ The online version of this article (available at http://www.jlr.org) contains one
TLDR
High-cholesterol diets elicit changes in gene expression via such transcription factors as sterol-regulatory element binding proteins (SREBPs) and liver X receptors (LXRs) and Affymetrix microarrays identified and confirmed six novel dietary cholesterol-regulated genes. Expand
Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone sites on the endothelium in the ApoE-deficient mouse.
TLDR
The levels, localization, and characteristics of expression of VCAM-1, ICAM-2, and PECam-1 appear to be differentially regulated, and upregulation of VC AM-1 and ICAM -1 is associated with sites of lesion formation. Expand
Common SNPs in HMGCR in Micronesians and Whites Associated With LDL-Cholesterol Levels Affect Alternative Splicing of Exon13
TLDR
A functional SNP in intron13 (rs3846662) was identified, which was in linkage disequilibrium with the SNPs of genome-wide significance and affected alternative splicing of HMGCR mRNA. Expand
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