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HD protein, human

Known as: Huntington disease protein, human, HTT protein, human, Huntingtin 
Huntingtin (3144 aa, ~348 kDa) is encoded by the human HTT gene. This protein may be involved in the regulation of vesicular transport.
National Institutes of Health

Related topics

Related topics

8 relations
Cellular MembraneHTT geneHuntington DiseaseLigand Binding

Broader (1)

Huntingtin Protein

Papers overview

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Highly Cited
2011
Highly Cited
2011
Sirt1 mediates neuroprotection from mutant huntingtin by activation of TORC1 and CREB transcriptional pathway
Sirt1, a NAD-dependent protein deacetylase, has emerged as a key regulator of mammalian transcription in response to cellular… 
Highly Cited
2007
Highly Cited
2007
Huntingtin facilitates dynein/dynactin-mediated vesicle transport
Cytoplasmic dynein is a multisubunit microtubule motor complex that, together with its activator, dynactin, drives vesicular… 
Highly Cited
2006
Highly Cited
2006
Mutant huntingtin aggregates impair mitochondrial movement and trafficking in cortical neurons
Highly Cited
2006
Highly Cited
2006
Interaction of Huntingtin-associated Protein-1 with Kinesin Light Chain
Huntingtin-associated protein-1 (HAP1) was initially identified as an interacting partner of huntingtin, the Huntington disease… 
Highly Cited
2005
Highly Cited
2005
Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions.
We have serendipitously established a mouse that expresses an N-terminal human huntingtin (htt) fragment with an expanded… 
Review
2004
Review
2004
Huntingtin-protein interactions and the pathogenesis of Huntington's disease.
Highly Cited
2004
Highly Cited
2004
Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation.
Highly Cited
2001
Highly Cited
2001
Mutant Huntingtin Enhances Excitotoxic Cell Death
Evidence suggests overactivation of NMDA-type glutamate receptors (NMDARs) contributes to selective degeneration of medium-sized… 
Highly Cited
2001
Highly Cited
2001
Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo.
We have developed yeast artificial chromosome (YAC) transgenic mice expressing normal (YAC18) and mutant (YAC46 or YAC72) human… 
Highly Cited
2000
Highly Cited
2000
Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity
Huntington disease (HD) is caused by expansion of a glutamine repeat in the amino-terminal region of huntingtin. Despite its… 
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