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Mutant dynactin in motor neuron disease
The results show that dysfunction of dynactin-mediated transport can lead to human motor neuron disease. Expand
Differential Regulation of Dynein and Kinesin Motor Proteins by Tau
The differential modulation of dynein and kinesin motility suggests that MAPs can spatially regulate the balance of microtubule-dependent axonal transport. Expand
Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons
Autophagosome biogenesis and maturation in primary neurons is a constitutive process that is spatially and temporally regulated along the axon.
Axonal Transport: Cargo-Specific Mechanisms of Motility and Regulation
An overview of axonal transport pathways is provided and their role in neuronal function is discussed and Retrograde transport, which plays a major role in neurotrophic and injury response signaling, is discussed. Expand
Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation
  • Y. Wong, E. Holzbaur
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 7 October 2014
An important role for optineurin is established as an autophagy receptor in parkin-mediated mitophagy and demonstrates that defects in a single pathway can lead to neurodegenerative diseases with distinct pathologies. Expand
Disruption of Dynein/Dynactin Inhibits Axonal Transport in Motor Neurons Causing Late-Onset Progressive Degeneration
A mouse model that confirms the critical role of disrupted axonal transport in the pathogenesis of motor neuron degenerative disease is described, and dynamitin overexpression was found to disassemble dynactin, a required activator of cytoplasmic dynein, resulting in an inhibition of retrograde axonal Transport. Expand
Motor Coordination via a Tug-of-War Mechanism Drives Bidirectional Vesicle Transport
Observations indicate that vesicles move robustly with a small complement of tightly bound motors and suggest an efficient regulatory scheme for bidirectional motility where small changes in the number of engaged motors manifest in largeChanges in the motility of cargo. Expand
Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin.
HAP1 might function as an adaptor protein using coiled coils to mediate interactions among cytoskeletal, vesicular and motor proteins, which could contribute to the neuronal dysfunction and death seen in HD. Expand
Huntingtin facilitates dynein/dynactin-mediated vesicle transport
Findings indicate that Htt binds to dynein and acts in a complex along with dynactin and Htt-associated protein-1 to facilitate vesicular transport. Expand
The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1).
Results demonstrate that p150Glued, a protein implicated in cytoplasmic dynein-based microtubule motility, is capable of direct binding to both microtubules and centractin. Expand