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Huntingtin Protein

Known as: Huntingtin Protein [Chemical/Ingredient], Huntington Disease Protein, IT15 Protein 
A protein that is highly expressed in the nervous system as well as other tissues; its size and structure vary due to polymorphisms. Expanded CAG… 
National Institutes of Health

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HD protein, humanHtt protein, rat
In BloodProcess of secretionagonistsantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Astrocyte transduction is required for rescue of behavioral phenotypes in the YAC128 mouse model with AAV-RNAi mediated HTT lowering therapeutics
Review
2019
Review
2019
Stem cells in animal models of Huntington disease: A systematic review
2013
2013
Deciphering the Roles of Trehalose and Hsp104 in the Inhibition of Aggregation of Mutant Huntingtin in a Yeast Model of Huntington’s Disease
Despite the significant amount of experimental data available on trehalose, the molecular mechanism responsible for its… 
Review
2012
Review
2012
Targeting mutant huntingtin for the development of disease-modifying therapy.
2011
2011
Dendritic spine loss and neurodegeneration is rescued by Rab11 in models of Huntington's disease
Although protein aggregates are a consistent feature of many neurodegenerative diseases, their role in the degenerative process… 
2009
2009
Tricyclic pyrone compounds prevent aggregation and reverse cellular phenotypes caused by expression of mutant huntingtin protein in striatal neurons
BackgroundHuntington's disease (HD) is a progressive neurodegenerative disorder caused by a CAG repeat expansion mutation in the… 
2008
2008
Dopamine D1 receptor–mediated aggregation of N-terminal fragments of mutant huntingtin and cell death in a neuroblastoma cell line
2007
2007
Ubiquitin‐proteasome system alterations in a striatal cell model of huntington's disease
Huntington's disease (HD) is a progressive, autosomal dominant neurodegenerative disease caused by an abnormally expanded CAG… 
Highly Cited
2005
Highly Cited
2005
Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment
2003
2003
Nucleocytoplasmic transport of huntingtin and Huntington's disease
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