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Huntingtin Protein

Known as: Huntingtin Protein [Chemical/Ingredient], Huntington Disease Protein, IT15 Protein 
A protein that is highly expressed in the nervous system as well as other tissues; its size and structure vary due to polymorphisms. Expanded CAG… 
National Institutes of Health

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HD protein, humanHtt protein, rat
In BloodProcess of secretionagonistsantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Astrocyte transduction is required for rescue of behavioral phenotypes in the YAC128 mouse model with AAV-RNAi mediated HTT lowering therapeutics
Review
2019
Review
2019
Stem cells in animal models of Huntington disease: A systematic review
2018
2018
Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy
Huntington's Disease (HD) is an inherited fatal neurodegenerative disease caused by a CAG expansion (≥36) in the first exon of… 
2016
2016
ENC1 Modulates the Aggregation and Neurotoxicity of Mutant Huntingtin Through p62 Under ER Stress
Huntington’s disease (HD) is a devastating neurodegenerative disorder, which is caused by the expression and aggregation of polyQ… 
2013
2013
Deciphering the Roles of Trehalose and Hsp104 in the Inhibition of Aggregation of Mutant Huntingtin in a Yeast Model of Huntington’s Disease
Despite the significant amount of experimental data available on trehalose, the molecular mechanism responsible for its… 
2012
2012
Caspase-6 Activity in a BACHD Mouse Modulates Steady-State Levels of Mutant Huntingtin Protein But Is Not Necessary for Production of a 586 Amino Acid Proteolytic Fragment
Huntington's disease (HD) is caused by a mutation in the huntingtin (htt) gene encoding an expansion of glutamine repeats at the… 
Review
2012
Review
2012
Targeting mutant huntingtin for the development of disease-modifying therapy.
2008
2008
Dopamine D1 receptor–mediated aggregation of N-terminal fragments of mutant huntingtin and cell death in a neuroblastoma cell line
Highly Cited
2005
Highly Cited
2005
Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment
2001
2001
Nuclear Relocation of Normal Huntingtin
In Huntington's Disease (HD), the huntingtin protein (Htt) includes an expanded polyglutamine domain. Since mutant Htt… 
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