Dendritic spine loss and neurodegeneration is rescued by Rab11 in models of Huntington's disease

@article{Richards2011DendriticSL,
  title={Dendritic spine loss and neurodegeneration is rescued by Rab11 in models of Huntington's disease},
  author={Paul Richards and Claire Martina Didszun and Susanna Campesan and Ashley V Simpson and B Horley and Kenneth W. Young and P. T. Glynn and Kelvin Cain and Charalambos P Kyriacou and Flaviano Giorgini and Pierluigi Nicotera},
  journal={Cell Death and Differentiation},
  year={2011},
  volume={18},
  pages={191-200}
}
Huntington's disease (HD) is a fatal neurodegenerative disorder caused by expansion of a polyglutamine tract in the huntingtin protein (htt) that mediates formation of intracellular protein aggregates. In the brains of HD patients and HD transgenic mice, accumulation of protein aggregates has been causally linked to lesions in axo-dendritic and synaptic compartments. Here we show that dendritic spines – sites of synaptogenesis – are lost in the proximity of htt aggregates because of functional… CONTINUE READING