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Guanylin, human

Known as: Guanylin, Guanylate Cyclase-Activating Protein I, Guanylate Cyclase-Activating Protein 1 
Guanylin (115 aa, ~12 kDa) is encoded by the human GUCA2A gene. This protein plays a role in the activation of intestinal guanylate cyclase.
National Institutes of Health

Papers overview

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Review
2004
Review
2004
  • L. Forte
  • Pharmacology & therapeutics
  • 2004
  • Corpus ID: 5731755
Guanylin, uroguanylin, and the bacterial heat-stable enterotoxin (ST) peptides comprise a new family of cyclic guanosine 3'-5… Expand
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Highly Cited
2003
Highly Cited
2003
Guanylin and uroguanylin, peptides synthesized in the intestine and kidney, have been postulated to have both paracrine and… Expand
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Highly Cited
1998
Highly Cited
1998
Guanylin is a mammalian peptide ligand that binds to the enterocyte receptor guanylyl cyclase C and mediates Cl- and HCO3- efflux… Expand
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Highly Cited
1996
Highly Cited
1996
BACKGROUND & AIMS Guanylin and heat-stable enterotoxin (STa) stimulate intestinal Cl- secretion via activation of the cystic… Expand
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Highly Cited
1994
Highly Cited
1994
Heat‐stable enterotoxins (STa) produced by pathogenic bacteria induce profound salt and water secretion in the gut, leading to… Expand
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Highly Cited
1994
Highly Cited
1994
Guanylin, a bioactive peptide, has recently been isolated from the intestine; this peptide activates intestinal guanylate cyclase… Expand
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Highly Cited
1994
Highly Cited
1994
Guanylin, a peptide homologue of the bacterial heat-stable enterotoxins (ST), is an endogenous activator of guanylate cyclase C… Expand
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Highly Cited
1993
Highly Cited
1993
The intestinal hormone guanylin and bacterial heat-stable enterotoxins (STs) are members of a peptide family that activates… Expand
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Highly Cited
1993
Highly Cited
1993
Intestinal salt and fluid secretion is stimulated by Escherichia coli heat-stable enterotoxins (ST) through activation of a… Expand
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Highly Cited
1992
Highly Cited
1992
Intestinal guanylate cyclase mediates the action of the heat-stable enterotoxin to cause a decrease in intestinal fluid… Expand
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