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Guanylin, human

Known as: Guanylin, Guanylate Cyclase-Activating Protein I, Guanylate Cyclase-Activating Protein 1 
Guanylin (115 aa, ~12 kDa) is encoded by the human GUCA2A gene. This protein plays a role in the activation of intestinal guanylate cyclase.
National Institutes of Health

Related topics

Related topics

8 relations
Colon structure (body structure)Enzyme InductionExtracellular SpaceGUCA2A gene

Broader (1)

Guanylate Cyclase-Activating Protein 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
The Proximal Convoluted Tubule is a Target for the Uroguanylin-regulated Natriuretic Response
Objectives and Methods: Guanylin and uroguanylin are peptides synthesized in the intestine and kidney that are postulated to have… 
Highly Cited
2002
Highly Cited
2002
Guanylin, Uroguanylin, and Heat-stable Euterotoxin Activate Guanylate Cyclase C and/or a Pertussis Toxin-sensitive G Protein in Human Proximal Tubule Cells*
Membrane guanylate cyclase C (GC-C) is the receptor for guanylin, uroguanylin, and heat-stable enterotoxin (STa) in the intestine… 
Review
2001
Review
2001
Guanylin family: new intestinal peptides regulating electrolyte and water homeostasis
The regulation of intestinal salt and water transport is critical to the maintenance of fluid volume. Control of this life… 
1998
1998
Uroguanylin: Gene structure, expression, processing as a peptide hormone, and co-storage with somatostatin in gastrointestinal D-cells
1997
1997
Increased plasma guanylin levels in patients with impaired renal function.
Guanylin, a 15-amino acid peptide, activates intestinal guanylate cyclase C receptor, thereby regulating intestinal fluid and… 
1997
1997
Effect and distribution of intravenously injected 125I-guanylin in rat kidney examined by high-resolution light microscopic radioautography
Abstract 125I-guanylin was injected intravenously into rats, and their kidney and intestinal tract were processed for light… 
1996
1996
Opossum colonic mucosa contains uroguanylin and guanylin peptides.
Uroguanylin and guanylin are structurally related peptides that activate an intestinal form of membrane guanylate cyclase (GC-C… 
Highly Cited
1995
Highly Cited
1995
Analysis of the human guanylin gene and the processing and cellular localization of the peptide.
The complete cell biological analysis of human guanylin, a recently discovered regulatory peptide, is offered in this… 
Highly Cited
1994
Highly Cited
1994
Enterochromaffin cells of the digestive system: cellular source of guanylin, a guanylate cyclase-activating peptide.
Guanylin, a bioactive peptide, has recently been isolated from the intestine; this peptide activates intestinal guanylate cyclase… 
Highly Cited
1992
Highly Cited
1992
Rat guanylin cDNA: characterization of the precursor of an endogenous activator of intestinal guanylate cyclase.
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