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A role for ghrelin in the central regulation of feeding
TLDR
It is shown that ghrelin is involved in the hypothalamic regulation of energy homeostasis and probably has a function in growth regulation by stimulating feeding and release of growth hormone.
Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems.
TLDR
The unique neuronal distribution of orexins and their functional activation of neural circuits suggest specific complex roles of the peptides in autonomic and neuroendocrine control.
Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion.
TLDR
It is demonstrated that nutritional state is a determinant of plasma ghrelin in humans andGhrelin secretion is up-regulated under conditions of negative energy balance and down-regulated in the setting of positive energy balance, suggesting the involvement of gh Relin in the regulation of feeding behavior and energy homeostasis.
The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats.
TLDR
This study indicated that the gastric vagal afferent is the major pathway conveying ghrelin's signals for starvation and GH secretion to the brain.
Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion.
TLDR
Findings indicate that ghrelin may regulate islet function in an endocrine and/or paracrine manner.
Ghrelin is present in pancreatic α-cells of humans and rats and stimulates insulin secretion
TLDR
Findings indicate that ghrelin may regulate islet function in an endocrine and/or paracrine manner.
Upregulation of Ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration.
TLDR
It is reported that ghrelin mRNA expression in the gastric fundus was increased, but that gh Relin peptide content decreased after a 48-h fast, suggesting that this novel gastrointestinal hormone plays a role in the regulation of energy balance.
Sympathetic and cardiovascular actions of orexins in conscious rats.
TLDR
Results indicate that central orexins regulate sympathetic nerve activity and affect cardiovascular functions, and suggest that renal sympathetic nerves play important roles in the homeostasis of body fluids and the circulatory system.
Distribution of orexin/hypocretin in the rat median eminence and pituitary.
A role for neuromedin U in stress response.
TLDR
Neuromedin U that interacts anatomically and/or functionally with the CRH system is a novel physiological regulator of stress response.
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