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Characterization of relA and codY mutants of Listeria monocytogenes: identification of the CodY regulon and its role in virulence
The results provide the first direct evidence that the activity of a CodY‐type protein influences pathogenesis and provides new information on the physiological adaptation of L.’monocytogenes to post‐exponential phase growth and virulence.
Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure
- R. Holtwick, M. Gotthardt, M. Kuhn
- Biology, MedicineProceedings of the National Academy of Sciences…
- 7 May 2002
Vascular GC-A is dispensable in the chronic and critical in the acute moderation of arterial blood pressure by ANP, resulting in mice in which vascular GC- A mRNA expression was reduced by ≈80%.
Molecular physiology of natriuretic peptide signalling
- M. Kuhn
- BiologyBasic Research in Cardiology
- 23 January 2004
The physiology and biochemistry of natriuretic peptides and their guanylyl cyclase receptors are reviewed, with special focus on the information gained to date from targeted disruption of members of this peptide family, their receptors, or effector molecules in the murine system.
Structure, regulation, and function of mammalian membrane guanylyl cyclase receptors, with a focus on guanylyl cyclase-A.
- M. Kuhn
- BiologyCirculation research
- 17 October 2003
The structure and functions of membrane GCs are discussed, with special emphasis on the physiological endocrine and cardiac functions of GC-A, the regulation of hormone-dependent GC- a activity, and the relevance of alterations of the atrial natriuretic peptide/GC-A system to cardiovascular diseases.
Vascular endothelium is critically involved in the hypotensive and hypovolemic actions of atrial natriuretic peptide.
GC-A-mediated increases in endothelial permeability are critically involved in the hypovolemic, hypotensive actions of ANP.
Function and dysfunction of mammalian membrane guanylyl cyclase receptors: lessons from genetic mouse models and implications for human diseases.
- M. Kuhn
- BiologyHandbook of experimental pharmacology
In contrast to the other orphan receptor GCs, GC-G has a broad tissue distribution in rodents, including the lung, intestine, kidney, skeletal muscle, and sperm, raising the possibility that there is another yet to be discovered family of cGMP-generating ligands.
Molecular Physiology of Membrane Guanylyl Cyclase Receptors.
- M. Kuhn
- BiologyPhysiological reviews
- 1 April 2016
Understanding of the mechanisms of signal transduction, regulation, and (dys)function of the membrane GCs, clarified their relevance for genetic and acquired diseases and, importantly, has revealed novel targets for therapies are clarified.
Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A.
- R. Holtwick, M. van Eickels, M. Kuhn
- Biology, MedicineThe Journal of clinical investigation
- 1 May 2003
Mice with cardiomyocyte-restricted GC-A deletion exhibited mild cardiac hypertrophy, and cardiac hypertrophic responses to aortic constriction were enhanced and accompanied by marked deterioration of cardiac function, consistent with a local function of the ANP/GC-A system to moderate the molecular program of cardiachypertrophy.
Guanylin strongly stimulates rat duodenal HCO3- secretion: proposed mechanism and comparison with other secretagogues.
The Guanylyl Cyclase-deficient Mouse Defines Differential Pathways of Natriuretic Peptide Signaling*
- M. J. Lopez, D. Garbers, M. Kuhn
- Biology, ChemistryThe Journal of Biological Chemistry
- 12 September 1997
Two natriuretic peptides (ANP, BNP) act through GC-A whereas another (CNP) acts through another receptor to regulate blood pressure, suggesting that this peptide acted through a receptor other thanGC-A.