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Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems.
The unique neuronal distribution of orexins and their functional activation of neural circuits suggest specific complex roles of the peptides in autonomic and neuroendocrine control.
Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor.
Central des-acyl ghrelin may activate orexin-expressing neurons, perhaps functioning in feeding regulation through interactions with a target protein distinct from the GHS-R.
Peptidomic Identification and Biological Validation of Neuroendocrine Regulatory Peptide-1 and -2*
Findings suggest that NERPs are novel modulators in body fluid homeostasis, and C-terminal amidation, a post-translational modification shared by many bioactive peptides, is focused on.
A role for neuropeptide W in the regulation of feeding behavior.
Data raise the possibility that NPW functions as an endogenous catabolic signaling molecule in the brain, as well as the biochemical and physiological functions of NPW, to better understand the hypothalamic regulation of energy homeostasis.
Urine and plasma levels of uroguanylin and its molecular forms in renal diseases.
It is suggested that bioactive uroguanylin-16 is involved in the regulation of electrolyte homeostasis and that the kidney participates in the metabolism and excretion of urogUanylin.
Neuroendocrine regulatory peptide-2 regulates feeding behavior via the orexin system in the hypothalamus.
The findings indicate that hypothalamic NERP-2 plays a role in the control of food intake and energy homeostasis via the orexin pathway, and serves as a precursor of multiple bioactive peptides exerting a diverse set of neuroendocrine functions.