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Gene Knockdown Techniques

Known as: Knock-Downs, Gene, Techniques, Gene Knockdown, Technique, Gene Knock-Down 
The artificial induction of GENE SILENCING by the use of RNA INTERFERENCE to reduce the expression of a specific gene. It includes the use of DOUBLE… 
National Institutes of Health

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2 relations
nursing therapystandards characteristics

Papers overview

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Highly Cited
2012
Highly Cited
2012
Tumor-secreted SDF-1 promotes glioma invasiveness and TAM tropism toward hypoxia in a murine astrocytoma model
A distinguishing feature of high-grade gliomas is the infiltration of neoplastic cells into adjacent brain tissues that mark most… 
Highly Cited
2010
Highly Cited
2010
Implication of Kir4.1 Channel in Excess Potassium Clearance: An In Vivo Study on Anesthetized Glial-Conditional Kir4.1 Knock-Out Mice
The Kir4.1 channel is crucial for the maintenance of the resting membrane potential of glial cells, and it is believed to play a… 
Highly Cited
2006
Highly Cited
2006
Multi-miRNA hairpin method that improves gene knockdown efficiency and provides linked multi-gene knockdown.
A number of natural microRNA (miRNA) hairpins have been found in clusters of multiple identical or different copies, suggesting… 
Highly Cited
2005
Highly Cited
2005
Endothelial Nitric Oxide Synthase Regulates Brain-Derived Neurotrophic Factor Expression and Neurogenesis after Stroke in Mice
Here, we investigate the effects of endothelial nitric oxide synthase (eNOS) on angiogenesis, neurogenesis, neurotrophic factor… 
Highly Cited
2005
Highly Cited
2005
Gene knockdown with intrathecal siRNA of NMDA receptor NR2B subunit reduces formalin-induced nociception in the rat
N-methyl-D-aspartate (NMDA) receptor activation, at the level of the spinal cord, has been shown to play an important role in the… 
Highly Cited
2005
Highly Cited
2005
Modifying the Subunit Composition of TASK Channels Alters the Modulation of a Leak Conductance in Cerebellar Granule Neurons
Two-pore domain potassium (K2P) channel expression is believed to underlie the developmental emergence of a potassium leak… 
Highly Cited
2004
Highly Cited
2004
Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference.
Gene expression analysis implicates an increasing number of novel genes in the brain as potential targets for the treatment of… 
Highly Cited
2004
Highly Cited
2004
Transfection microarray of human mesenchymal stem cells and on-chip siRNA gene knockdown.
Highly Cited
2003
Highly Cited
2003
A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA
We describe the use of lentiviral vectors expressing small interfering RNAs (siRNAs) to knock down the expression of specific… 
Highly Cited
2001
Highly Cited
2001
Inhibition of zebrafish fgf8 pre‐mRNA splicing with morpholino oligos: A quantifiable method for gene knockdown
Antisense morpholino oligonucleotides (MO) have been used successfully in zebrafish and Xenopus to knock down gene function by… 
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