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A Role for Piwi and piRNAs in Germ Cell Maintenance and Transposon Silencing in Zebrafish
It is demonstrated that zebrafish Piwi (Ziwi) is expressed in both the male and the female gonad and is a component of a germline-specifying structure called nuage, implicating a role for piRNAs in the silencing of repetitive elements in vertebrates. Expand
The pie-1 and mex-1 genes and maternal control of blastomere identity in early C. elegans embryos
It is shown here that maternal-effect mutations in the pie-1 and mex-1 genes cause additional 8-cell stage blastomeres to adopt a fate very similar to that of the wild-type MS blastomere. Expand
MEX-3 Is a KH Domain Protein That Regulates Blastomere Identity in Early C. elegans Embryos
It is shown that maternal-effect lethal mutations in the gene mex-3 cause descendants of the anterior blastomere to produce muscles by a pattern of development similar to that of a descendant of the wild-type posterior Blastomere. Expand
Identification of a retinoic acid-sensitive period during primary axis formation in Xenopus laevis.
RA sensitivity defines a labile intermediate that occurs during axial patterning of the primary body axis in embryos of the frog Xenopus laevis, and data suggest a possible role for RA in normal axis formation. Expand
The maternal genes apx-1 and glp-1 and establishment of dorsal-ventral polarity in the early C. elegans embryo
The glp-1 gene, a homolog of the Notch gene of Drosophila, functions in two distinct cell-cell interactions that specify the ABp and ABa fates. Expand
The maternal gene skn-1 encodes a protein that is distributed unequally in early C. elegans embryos
It is shown that the Skn-1 protein is nuclear localized and that P1 appears to accumulate markedly higher levels of Skn -1 protein than its sister, the AB blastomere, and that pie-1(+) activity may function to regulate the activity of SkN-1protein in the descendants of the posterior blastomeres P1. Expand
par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3.
A new gene, par-6, is identified, which acts in conjunction with other par genes to properly localize cytoplasmic components in the early embryo, and is very similar to that caused by mutations in a previously described gene,par-3. Expand
Zebrafish fgf24 functions with fgf8 to promote posterior mesodermal development
Both phenotypic and genetic evidence is provided that these Fgf signaling components interact with no tail and spadetail, two zebrafish T-box transcription factors that are required for the development of all posterior mesoderm. Expand
The zebrafish fgf24 mutant identifies an additional level of Fgf signaling involved in vertebrate forelimb initiation
It is shown that the zebrafish fgf24 gene, which belongs to the Fgf8/17/18 subfamily of FgF ligands, acts downstream of tbx5 to activate f gf10 expression in the lateral plate mesoderm, which relays the limb inducing signal to the overlying ectoderm. Expand
The role of actin filaments in patterning the Caenorhabditis elegans cuticle.
The pattern of furrows on the first larval cuticle of Caenorhabditis elegans is coincident with a pattern of submembranous actin filament bundles in the epithelial cells that secrete the cuticle, suggesting that conditions or mutations that affect the pattern of cuticle furrows might cause primary defects in the cytoskeletal organization of the epitocyte cells that Secrete the Cuticle. Expand