• Publications
  • Influence
Animal models of traumatic brain injury
Traumatic brain injury (TBI) is a leading cause of mortality and morbidity both in civilian life and on the battlefield worldwide. Survivors of TBI frequently experience long-term disabling changesExpand
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VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain.
VEGF is a secreted mitogen associated with angiogenesis and is also a potent vascular permeability factor. The biological role of VEGF in the ischemic brain remains unknown. This study was undertakenExpand
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Therapeutic Benefit of Intravenous Administration of Bone Marrow Stromal Cells After Cerebral Ischemia in Rats
Background and Purpose— We tested the hypothesis that intravenous infusion of bone marrow derived-marrow stromal cells (MSCs) enter the brain and reduce neurological functional deficits after strokeExpand
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Intravenous Administration of Human Umbilical Cord Blood Reduces Behavioral Deficits After Stroke in Rats
Background and Purpose— Human umbilical cord blood cells (HUCBC) are rich in stem and progenitor cells. In this study we tested whether intravenously infused HUCBC enter brain, survive,Expand
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Human marrow stromal cell therapy for stroke in rat: Neurotrophins and functional recovery
ObjectiveTo test the effect of IV-injected human bone marrow stromal cells (hMSC) on neurologic functional deficits after stroke in rats. Methods Rats were subjected to transient middle cerebralExpand
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Spinal cord injury in rat: treatment with bone marrow stromal cell transplantation
We tested the hypothesis that transplantation of bone marrow stromal cells (MSCs) into the spinal cord after a contusion injury promotes functional outcome. Rats (n = 31) were subjected to a weightExpand
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Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia
Progenitor cells in the subventricular zone of the lateral ventricle and in the dentate gyrus of the hippocampus can proliferate throughout the life of the animal. To examine the proliferation andExpand
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Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat
  • J. Chen, Y. Li, +6 authors M. Chopp
  • Biology, Medicine
  • Journal of neuroscience research
  • 15 September 2003
The present study investigates the induction of neurogenesis, reduction of apoptosis, and promotion of basic fibroblast growth factor (bFGF) expression as possible mechanisms by which treatment ofExpand
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Intravenous Administration of Human Bone Marrow Stromal Cells Induces Angiogenesis in the Ischemic Boundary Zone After Stroke in Rats
Abstract— We tested the hypothesis that intravenous infusion of human bone marrow stromal cells (hMSCs) promotes vascular endothelial growth factor (VEGF) secretion, VEGF receptor 2 (VEGFR2)Expand
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Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic
Restorative cell-based and pharmacological therapies for experimental stroke substantially improve functional outcome. These therapies target several types of parenchymal cells (including neural stemExpand
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