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Gemcitabine Elaidate

Known as: Gemcitabine 5'-Elaidic Acid Ester 
A lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential… 
National Institutes of Health

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CP 4126
DNA Synthesis InhibitionNucleotide BiosynthesisPositive Regulation of ApoptosisRibonucleotide Reductase

Papers overview

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2016
2016
First-in-human study of a novel nucleoside analogue, CP-4126, in patients with advanced solid tumors.
2577 Background: CP-4126 (gemcitabine 5'-elaidic acid ester) is a novel nucleoside analogue with proven preclinical antitumor… 
2015
2015
A first-in-human phase I and pharmacokinetic study of CP-4126 (CO-101), a nucleoside analogue, in patients with advanced solid tumours
AbstractBackground CP-4126 (gemcitabine elaidate, previously CO-101) is a lipid–drug conjugate of gemcitabine designed to… 
2004
2004
Esterase-18 (ES-18) of the house mouse (Mus musculus): Biochemical characterization and genetics of an allozyme system linked to chromosome 19
This study describes the biochemical characterization, genetic variation, and linkage of a codominantly inherited murine esterase… 
Highly Cited
1999
Highly Cited
1999
Both (n-3) and (n-6) fatty acids stimulate wound healing in the rat intestinal epithelial cell line, IEC-6.
The control of proliferation and epithelial restitution are processes that are poorly understood. The effects of (n-3), (n-6) and… 
1988
1988
Esterase-18 (ES-18) of the house mouse (Mus musculus): Biochemical characterization and genetics of an allozyme system linked to chromosome 19
This study describes the biochemical characterization, genetic variation, and linkage of a codominantly inherited murine esterase… 
1980
1980
Fluorimetric assay of the activity of extracellular lipases of Pseudomonas fluorescens and Serratia marcescens.
A fluorimetric assay was carried out on the activity of extracellular lipase concentrations obtained from Serratia marcescens and… 
1976
1976
Dual-labeled technique for human lipid metabolism studies using deuterated fatty acid isomers
Two deuterated fatty acids, elaidate-d2 and oleate-d4, were fed simultaneously to a human subject as a mixture of trielaidin-d6… 
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