Skip to search formSkip to main contentSkip to account menu

CP 4126

Known as: CP-4126, CP4126 
National Institutes of Health

Related topics

Related topics

5 relations

Narrower (2)

CA-101CO-101

Broader (2)

DeoxycytidineGemcitabine Elaidate
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
First-in-human study of a novel nucleoside analogue, CP-4126, in patients with advanced solid tumors.
2577 Background: CP-4126 (gemcitabine 5'-elaidic acid ester) is a novel nucleoside analogue with proven preclinical antitumor… 
2015
2015
A first-in-human phase I and pharmacokinetic study of CP-4126 (CO-101), a nucleoside analogue, in patients with advanced solid tumours
AbstractBackground CP-4126 (gemcitabine elaidate, previously CO-101) is a lipid–drug conjugate of gemcitabine designed to… 
Review
2014
Review
2014
Novel Developments in the Use of Antimetabolites
Antimetabolites are the most widely used and most efficacious group of anticancer drugs. Antimetabolites are also the oldest… 
2013
2013
Phase I study of oral CP-4126, a gemcitabine derivative, in patients with advanced solid tumors
SummaryCP-4126 is a gemcitabine (2′,2′-difluorodeoxycytidine; dFdC) 5′ elaidic acid ester. The purpose of this dose-escalating… 
2010
2010
The Activity of the Lipophilic Nucleoside Derivatives Elacytarabine and CP-4126 in a Panel of Tumor Cell Lines Resistant to Nucleoside Analogues
The clinical activity of pyrimidine analogues (araC and gemcitabine) is impaired by different mechanisms of resistance and… 
2010
2010
Induction of Resistance to the Lipophilic Cytarabine Prodrug Elacytarabine (CP-4055) in CEM Leukemic Cells
The deoxynucleoside analogs cytarabine (Ara-C) and gemcitabine (dFdC) are widely used in the treatment of cancer. Due to their… 
2010
2010
Phase II study of CP-4126, a gemcitabine-lipid conjugate, in patients with advanced pancreatic cancer.
e14674 Background: Uptake of hydrophilic nucleoside analogues into tumor cells is determined by membrane transporter expression… 
2010
2010
Phase I study of oral CP-4126, a gemcitabine analog, in patients with advanced solid tumors.
e13078 Background: CP-4126 (gemcitabine-5′-elaidic acid ester) is a novel nucleoside analogue with preclinical antitumor activity… 
Review
2009
Review
2009
CP‐4055 and CP‐4126 are active in ara‐C and gemcitabine‐resistant lymphoma cell lines
Albano, F., Anelli, L., Zagaria, A., Archidiacono, N., Liso, V., Rocchi, M. & Specchia, G. (2007) ‘‘Home-brew’’ FISH assay shows… 
2009
2009
Cell cycle effects of fatty acid derivatives of cytarabine, CP-4055, and of gemcitabine, CP-4126, as basis for the interaction with oxaliplatin and docetaxel.
To bypass resistance due to limited entry into the cell derivatives of cytarabine (CP-4055, elacytarabine) and gemcitabine (CP… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)