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GRLF1 wt Allele

Known as: ARHGAP35, KIAA1722, p190ARhoGAP 
Human GRLF1 wild-type allele is located in the vicinity of 19q13.32 and is approximately 86 kb in length. This allele, which encodes glucocorticoid… 
National Institutes of Health

Related topics

Related topics

9 relations
19q13.32ARHGAP35 protein, humanFocal adhesion pathwayPDGFR-beta Signaling Pathway

Broader (1)

ARHGAP35 gene

Papers overview

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Highly Cited
2012
Highly Cited
2012
Protein Tyrosine Phosphatase Receptor Type Z Negatively Regulates Oligodendrocyte Differentiation and Myelination
Background Fyn tyrosine kinase-mediated down-regulation of Rho activity through activation of p190RhoGAP is crucial for… 
Highly Cited
2008
Highly Cited
2008
p190RhoGAP is the convergence point of adhesion signals from α5β1 integrin and syndecan-4
The fibronectin receptors α5β1 integrin and syndecan-4 cocluster in focal adhesions and coordinate cell migration by making… 
Highly Cited
2007
Highly Cited
2007
Filamin links cell shape and cytoskeletal structure to Rho regulation by controlling accumulation of p190RhoGAP in lipid rafts
Cytoskeleton-dependent changes in the activity of the small GTPase Rho mediate the effects of cell shape on cell function… 
Highly Cited
2006
Highly Cited
2006
Integrin signaling through Arg activates p190RhoGAP by promoting its binding to p120RasGAP and recruitment to the membrane.
The Rho family GTPases RhoA (Rho), Rac1, and Cdc42 are essential effectors of integrin-mediated cell attachment and spreading… 
Review
2004
Review
2004
Adhesion-Dependent Regulation of p190RhoGAP in the Developing Brain by the Abl-Related Gene Tyrosine Kinase
Highly Cited
2003
Highly Cited
2003
Cadherin Engagement Inhibits RhoA via p190RhoGAP*
Cadherins are transmembrane receptors that mediate cell-cell adhesion in epithelial cells. A number of changes occur during… 
Highly Cited
2003
Highly Cited
2003
p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human chromosome 19q13.3.
p190RhoGAP and Rho are key regulators of oligodendrocyte differentiation. The gene encoding p190RhoGAP is located at 19q13.3 of… 
Highly Cited
2002
Highly Cited
2002
Localized suppression of RhoA activity by Tyr31/118-phosphorylated paxillin in cell adhesion and migration
RhoA activity is transiently inhibited at the initial phase of integrin engagement, when Cdc42- and/or Rac1-mediated membrane… 
Highly Cited
2001
Highly Cited
2001
RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity.
The binding of extracellular matrix proteins to integrins triggers rearrangements in the actin cytoskeleton by regulating the Rho… 
Highly Cited
1995
Highly Cited
1995
p190-B, a New Member of the Rho GAP Family, and Rho Are Induced to Cluster after Integrin Cross-linking (*)
p120 forms distinct complexes with two phosphoproteins, p62 and p190. Here we have cloned a cDNA encoding a protein with 51… 
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