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Cell Migration: Integrating Signals from Front to Back
Cell migration is a highly integrated multistep process that orchestrates embryonic morphogenesis; contributes to tissue repair and regeneration; and drives disease progression in cancer, mentalExpand
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Focal adhesions, contractility, and signaling.
Focal adhesions are sites of tight adhesion to the underlying extracellular matrix developed by cells in culture. They provided a structural link between the actin cytoskeleton and the extracellularExpand
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P120 Catenin Regulates the Actin Cytoskeleton via Rho Family Gtpases
Cadherins are calcium-dependent adhesion molecules responsible for the establishment of tight cell–cell contacts. p120 catenin (p120ctn) binds to the cytoplasmic domain of cadherins in theExpand
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Rho-stimulated contractility drives the formation of stress fibers and focal adhesions
Activated rhoA, a ras-related GTP-binding protein, stimulates the appearance of stress fibers, focal adhesions, and tyrosine phosphorylation in quiescent cells (Ridley, A.J., and A. Hall, 1992. Cell.Expand
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Rho and Rac Take Center Stage
Many features of cell behavior are regulated by Rho family GTPases, but the most profound effects of these proteins are on the actin cytoskeleton and it was these that first drew attention to thisExpand
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Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton.
INTRODUCTION 487 MORPHOLOGY AND OBSERVATION OF FOCAL ADHESIONS 488 FORMATION OF FOCAL ADHESIONS 490 DYNAMICS OF FOCAL ADHESION COMPONENTS ...... 491
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Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly
Cells in culture reveal high levels of protein tyrosine phosphorylation in their focal adhesions, the regions where cells adhere to the underlying substratum. We have examined the tyrosineExpand
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Cadherin Engagement Regulates Rho family GTPases*
The formation of cell-cell adherens junctions is a cadherin-mediated process associated with reorganization of the actin cytoskeleton. Because Rho family GTPases regulate actin dynamics, weExpand
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Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism
The Rho family GTPases Cdc42, Rac1 and RhoA control many of the changes in the actin cytoskeleton that are triggered when growth factor receptors and integrins bind their ligands [1] [2]. Rac1 andExpand
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Regulation of RhoGTPase crosstalk, degradation and activity by RhoGDI1
At steady state, most Rho GTPases are bound in the cytosol to Rho guanine nucleotide dissociation inhibitors (RhoGDIs). RhoGDIs have generally been considered to hold Rho proteins passively in anExpand
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