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Transcriptome-wide noise controls lineage choice in mammalian progenitor cells
TLDR
Clonal heterogeneity of gene expression level is not due to independent noise in the expression of individual genes, but reflects metastable states of a slowly fluctuating transcriptome that is distinct in individual cells and may govern the reversible, stochastic priming of multipotent progenitor cells in cell fate decision.
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Bifurcation dynamics in lineage-commitment in bipotent progenitor cells.
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Nucleolar Components Involved in Ribosome Biogenesis Cycle between the Nucleolus and Nucleoplasm in Interphase Cells
TLDR
It is suggested that the rapid exchange of nucleolar components between the nucleolus and nucleoplasm may represent a new level of regulation for rRNA synthesis.
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Reprogramming cell fates: reconciling rarity with robustness
  • Sui Huang
  • Biology
    BioEssays : news and reviews in molecular…
  • 1 May 2009
TLDR
A pedagogical primer to the fundamental principles of gene regulatory networks as integrated dynamic systems as well as recent insights in gene expression noise and fate determination are provided, thereby offering a formal framework that may help to understand why cell fate reprogramming events are inherently rare and yet so robust.
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High-Betweenness Proteins in the Yeast Protein Interaction Network
TLDR
It is found that proteins with high betweenness are more likely to be essential and that evolutionary age of proteins is positively correlated with betweenness, which suggests the existence of some modular organization of the network, and that the high-betweenness, low-connectivity proteins may act as important links between these modules.
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Cancer attractors: a systems view of tumors from a gene network dynamics and developmental perspective.
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Gene Expression Dynamics Inspector (GEDI): for integrative analysis of expression profiles
TLDR
A Gene Expression Dynamics Inspector (GEDI) is described that uses self-organizing maps to translate high-dimensional expression profiles of time courses or sample classes into animated, coherent and robust mosaics images.
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Cell fates as high-dimensional attractor states of a complex gene regulatory network.
Cells in multicellular organisms switch between distinct cell fates, such as proliferation or differentiation into specialized cell types. Genome-wide gene regulatory networks govern this behavior.…
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Gene expression profiling, genetic networks, and cellular states: an integrating concept for tumorigenesis and drug discovery
  • Sui Huang
  • Biology
    Journal of Molecular Medicine
  • 1 June 1999
TLDR
A global (genome-wide) view of "gene function" in the regulation of the dynamic relationship between proliferation, differentiation, and apoptosis can provide new insights into cellular homeostasis and the origins of neoplasia.
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Stemness of the hybrid Epithelial/Mesenchymal State in Breast Cancer and Its Association with Poor Survival
TLDR
The data support a novel model that links a mixed EM signature with stemness in individual cells, luminal and basal cell lines, in vivo xenograft mouse models, and in all breast cancer subtypes and suggest that targeting E/M heterogeneity by eliminating hybrid E-M cells and cooperation between E and M cell-types could improve breast cancer patient survival independent of breast cancer-subtype.
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