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In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases
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Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta.
TLDR
PTN is the first natural ligand identified for any of the RPTP family; its identification provides a unique tool to pursue the novel signaling pathway activated by PTN and the relationship of PTN signaling with other pathways regulating beta-catenin.
View on PubMed
Identification of Retinal Ganglion Cells and Their Projections Involved in Central Transmission of Information about Upward and Downward Image Motion
TLDR
These findings provide insights into the neural mechanisms of OKR, how information about the direction of image motion is deciphered by the AOS, and whether information about upward and downward image motion transmitted by distinct ON DS cells is separately processed in the MTN.
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Pleiotrophin signals increased tyrosine phosphorylation of β-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase β/ζ
TLDR
PTN is the first natural ligand identified for any of the RPTP family and its identification provides a unique tool to pursue the novel signaling pathway activated by PTN and the relationship of PTN signaling with other pathways regulating β-catenin.
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A missense mutation of the Na+ channel αII subunit gene Nav1.2 in a patient with febrile and afebrile seizures causes channel dysfunction
TLDR
A mutation resulting in an amino acid exchange (R187W) in the gene encoding the α-subunit of neuronal voltage-gated Na+ channel type II (Nav1.2) in a patient with FS associated with afebrile seizures is reported and the R187W mutation is proposed as the genetic defect responsible for febrile epileptic seizures.
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Identification of RALDH-3, a novel retinaldehyde dehydrogenase, expressed in the ventral region of the retina
View on Elsevier
Molecular Characterization of CRMP5, a Novel Member of the Collapsin Response Mediator Protein Family*
TLDR
The results suggest that CRMP complexes in the developing nervous system are classifiable into two populations that contain either CRMP1 or CRMP5, which indicates that different complexes may have distinct functions in shaping the neural networks.
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Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori
TLDR
It is reported that mice deficient in protein tyrosine phosphatase receptor type Z (Ptprz) do not show mucosal damage by VacA, although VacA is incorporated into the gastric epithelial cells to the same extent as in wild-type mice, and pleiotrophin (PTN), an endogenous ligand of Ptprz, induced gastritis specifically in PtprZ+/+ mice when administered orally.
View on Nature
Axonal morphogenesis controlled by antagonistic roles of two CRMP subtypes in microtubule organization
TLDR
It is found that novel subtypes of collapsin response mediator proteins (CRMP‐As and the originals), which occur from the alternative usage of different first coding exons, are involved in this conversion of microtubule patterns.
View on Wiley
Ventroptin: A BMP-4 Antagonist Expressed in a Double-Gradient Pattern in the Retina
TLDR
The chick Ventroptin is identified as an antagonist of bone morphogenetic protein 4 (BMP-4), which is mainly expressed in the ventral retina, not only with a ventral high–dorsal low gradient but also with a nasal high–temporal low gradient at later stages.
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