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GNLY protein, human

Known as: TLA519 protein, human, T-lymphocyte activation gene 519 protein, human, Lymphokine LAG-2 
Granulysin (145 aa, ~16 kDa) is encoded by the human GNLY gene. This protein is involved in the antimicrobial activity of cytotoxic granules of… 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (1)

Antigens, Differentiation, T-Lymphocyte
Antimicrobial EffectCytotoxic Granule ProteinGNLY geneImmune System Processes

Papers overview

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Review
2004
Review
2004
σ Factors and Global Gene Regulation in Mycobacterium tuberculosis
Tuberculosis remains a worldwide threat despite the availability of the BCG vaccine and antibiotic treatment. It is estimated… 
Highly Cited
2003
Highly Cited
2003
Human NKT Cells Express Granulysin and Exhibit Antimycobacterial Activity 1
Human NKT cells are a unique subset of T cells that express an invariant Vα24 TCR that recognizes the nonclassical Ag-presenting… 
Highly Cited
2003
Highly Cited
2003
Granulysin crystal structure and a structure-derived lytic mechanism.
Highly Cited
2003
Highly Cited
2003
Intracellular Mediators of Granulysin-Induced Cell Death 1
Granulysin, a molecule present in the granules of CTL and NK cells, is cytolytic against microbes and tumors. Granulysin induces… 
Highly Cited
2001
Highly Cited
2001
T-cell release of granulysin contributes to host defense in leprosy
A novel mechanism by which T cells contribute to host defense against microbial pathogens is release of the antimicrobial protein… 
Highly Cited
2001
Highly Cited
2001
Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by Vgamma9/Vdelta2 T lymphocytes.
Contribution of Vgamma9/Vdelta2 T lymphocytes to immune protection against Mycobacterium tuberculosis is still a matter of debate… 
Highly Cited
2000
Highly Cited
2000
Bactericidal and Tumoricidal Activities of Synthetic Peptides Derived from Granulysin1
Granulysin, a 9-kDa protein localized to human CTL and NK cell granules, is cytolytic against tumor cells and microbes. Molecular… 
Highly Cited
1999
Highly Cited
1999
Identification of an anti-mycobacterial domain in NK-lysin and granulysin.
NK-lysin and granulysin are homologous cationic anti-bacterial peptides produced by pig and human cytolytic lymphocytes… 
Highly Cited
1998
Highly Cited
1998
Granulysin-induced apoptosis. I. Involvement of at least two distinct pathways.
Granulysin is a newly described cytolytic molecule released by CTL and NK cells via granule-mediated exocytosis. It shares… 
Review
1997
Review
1997
Granulysin, a new human cytolytic granule-associated protein with possible involvement in cell-mediated cytotoxicity.
A primary process by which cytotoxic T lymphocytes (CTL) and natural killer (NK) cells lyse target cells involves the regulated… 
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