• Publications
  • Influence
Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels
Eukaryotic cells contain assemblies of RNAs and proteins termed RNA granules. Many proteins within these bodies contain KH or RRM RNA-binding domains as well as low complexity (LC) sequences ofExpand
  • 1,121
  • 98
  • PDF
Toward the structural genomics of complexes: crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis.
The developing science called structural genomics has focused to date mainly on high-throughput expression of individual proteins, followed by their purification and structure determination. InExpand
  • 638
  • 73
  • PDF
Atomic structures of amyloid cross-β spines reveal varied steric zippers
Amyloid fibrils formed from different proteins, each associated with a particular disease, contain a common cross-β spine. The atomic architecture of a spine, from the fibril-forming segment GNNQQNYExpand
  • 1,580
  • 56
  • PDF
Structure of the cross-beta spine of amyloid-like fibrils.
Numerous soluble proteins convert to insoluble amyloid-like fibrils that have common properties. Amyloid fibrils are associated with fatal diseases such as Alzheimer's, and amyloid-like fibrils canExpand
  • 544
  • 53
Atomic structures of amyloid cross-beta spines reveal varied steric zippers.
Amyloid fibrils formed from different proteins, each associated with a particular disease, contain a common cross-beta spine. The atomic architecture of a spine, from the fibril-forming segmentExpand
  • 528
  • 53
Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence.
The reaction catalyzed by Escherichia coli dihydrofolate reductase (ecDHFR) cycles through five detectable kinetic intermediates: holoenzyme, Michaelis complex, ternary product complex,Expand
  • 518
  • 40
Crystal Structure of T7 Gene 4 Ring Helicase Indicates a Mechanism for Sequential Hydrolysis of Nucleotides
We have determined the crystal structure of an active, hexameric fragment of the gene 4 helicase from bacteriophage T7. The structure reveals how subunit contacts stabilize the hexamer. DeviationExpand
  • 462
  • 38
Structure of the cross-β spine of amyloid-like fibrils
Numerous soluble proteins convert to insoluble amyloid-like fibrils that have common properties. Amyloid fibrils are associated with fatal diseases such as Alzheimer's, and amyloid-like fibrils canExpand
  • 1,230
  • 28
  • PDF
Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules
Plethora of Secretory Amyloids Protein aggregation and the formation of amyloids are associated with several dozen pathological conditions in humans, including Alzheimer's disease, Parkinson'sExpand
  • 706
  • 27
  • PDF
Protein Structures Forming the Shell of Primitive Bacterial Organelles
Bacterial microcompartments are primitive organelles composed entirely of protein subunits. Genomic sequence databases reveal the widespread occurrence of microcompartments across diverse microbes.Expand
  • 359
  • 25