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GMNN gene

Known as: geminin, DNA replication inhibitor, GEMININ, Gem 
This gene plays a role in DNA replication regulation.
National Institutes of Health

Related topics

Related topics

4 relations
Cell Cycle ControlGemininNegative Regulation of Cell Cycle

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GMNN protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Human cytomegalovirus miR-US5-1 inhibits viral replication by targeting Geminin mRNA
Viruses commonly create favorable cellular conditions for their survival through multiple mechanisms. MicroRNAs (miRNAs), which… 
2015
2015
Geminin is Essential to Prevent DNA Re‐Replication‐Dependent Apoptosis in Pluripotent Cells, but not in Differentiated Cells
Geminin is a dual‐function protein unique to multicellular animals with roles in modulating gene expression and preventing DNA re… 
2013
2013
The Geminin and Idas Coiled Coils Preferentially Form a Heterodimer That Inhibits Geminin Function in DNA Replication Licensing*
Background: Idas is a homologue of the proliferation and differentiation regulator, Geminin. Results: Idas and Geminin form… 
2010
2010
Differential Geminin Requirement for Proliferation of Thymocytes and Mature T Cells
Stem/progenitor cells coordinate proliferation and differentiation, giving rise to appropriate cell numbers of functionally… 
2010
2010
Preferential Re-Replication of Drosophila Heterochromatin in the Absence of Geminin
To ensure genomic integrity, the genome must be duplicated exactly once per cell cycle. Disruption of replication licensing… 
2010
2010
Geminin, Ki67, and minichromosome maintenance 2 in gastric hyperplastic polyps, adenomas, and intestinal-type carcinomas: pathobiological significance
BackgroundGeminin negatively regulates Cdt1 and induces the formation of prereplicative complexes by loading mini-chromosome… 
2007
2007
Geminin Prevents Rereplication during Xenopus Development*
To maintain a stable genome, it is essential that replication origins fire only once per cell cycle. The protein Geminin is… 
2005
2005
Mcm 2 , Geminin , and KI 67 Define Proliferative State and Are PrognosticMarkers in Renal Cell Carcinoma
Purpose: The origin licensing factors minichromosome maintenance 2 (Mcm2) and Geminin have recently been identified as critical… 
Highly Cited
2004
Highly Cited
2004
Intrinsic nuclear import activity of geminin is essential to prevent re‐initiation of DNA replication in Xenopus eggs
Prior to S phase, eukaryotic chromosomes are licensed for initiation of DNA replication, and re‐licensing is prohibited after S… 
2004
2004
The destruction box of human Geminin is critical for proliferation and tumor growth in human colon cancer cells
A domain-specific disruption was performed on the destruction box sequence of endogenous Geminin gene, an inhibitor of the DNA… 
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