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Genomic changes frequently occur in cancer cells during tumorigenesis from normal cells. Using the Illumina Human NS-12 single… Expand BACKGROUND
Gene expression profiling data for human primary cutaneous melanomas are scarce because of the lack of retrospective… Expand Purpose: The origin licensing factors minichromosome maintenance 2 (Mcm2) and Geminin have recently been identified as critical… Expand Eukaryotic genomes are replicated from large numbers of replication origins distributed on multiple chromosomes. The activity of… Expand Organogenesis in vertebrates requires the tight control of cell proliferation and differentiation. The homeobox-containing… Expand ABSTRACT Genomic DNA replication is tightly controlled to ensure that DNA replication occurs once per cell cycle; loss of this… Expand Licensing of replication origins is carefully regulated in a cell cycle to maintain genome integrity. Using an in vivo… Expand ABSTRACT Alteration of the control of DNA replication and mitosis is considered to be a major cause of genome instability. To… Expand A hypomorphic mutation made in the ORC2 gene of a human cancer cell line through homologous recombination decreased Orc2 protein… Expand In all eukaryotic organisms, inappropriate firing of replication origins during the G2 phase of the cell cycle is suppressed by… Expand