GMNN protein, human

Known as: geminins, geminin protein, human, geminin, DNA replication inhibitor protein, human 
Geminin (209 aa, ~24 kDa) is encoded by the human GMNN gene. This protein is involved in the modulation of DNA replication.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Tetraploidization has been proposed as an intermediate step toward aneuploidy in human cancer but a general mechanism for the… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Cdt1, a protein essential in G1 for licensing of origins for DNA replication, is inhibited in S-phase, both by binding to geminin… (More)
Is this relevant?
Highly Cited
2006
Highly Cited
2006
The initiation of DNA replication is tightly regulated in eukaryotic cells to ensure that the genome is precisely duplicated once… (More)
Is this relevant?
Highly Cited
2005
Highly Cited
2005
In eukaryotes, prereplication complexes (pre-RCs) containing ORC, Cdc6, Cdt1, and MCM2-7 are assembled on chromatin in the G1… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Protein microarrays provide a powerful tool for the study of protein function. However, they are not widely used, in part because… (More)
  • figure 4
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Strict regulation of DNA replication is essential to ensure proper duplication and segregation of chromosomes during the cell… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2004
Highly Cited
2004
The cohesin complex is a central player in sister chromatid cohesion, a process that ensures the faithful segregation of… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Organogenesis in vertebrates requires the tight control of cell proliferation and differentiation. The homeobox-containing… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 1
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Alteration of the control of DNA replication and mitosis is considered to be a major cause of genome instability. To investigate… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
A hypomorphic mutation made in the ORC2 gene of a human cancer cell line through homologous recombination decreased Orc2 protein… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?