• Publications
  • Influence
A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro.
In earlier studies, we provided statistical evidence that individual differences in the angiotensinogen gene, the precursor of the vasoactive hormone angiotensin II, constitute inheritedExpand
  • 549
  • 23
  • PDF
Susceptibility loci for intracranial aneurysm in European and Japanese populations
Stroke is the world's third leading cause of death. One cause of stroke, intracranial aneurysm, affects ∼2% of the population and accounts for 500,000 hemorrhagic strokes annually in mid-life (medianExpand
  • 250
  • 14
Haplotypes of angiotensinogen in essential hypertension.
The M235T polymorphism of the angiotensinogen gene (AGT) has been associated with essential and pregnancy-induced hypertension. Generation of haplotypes can help to resolve whether the T235 alleleExpand
  • 292
  • 13
Genome-wide association study of intracranial aneurysm identifies three new risk loci
Saccular intracranial aneurysms are balloon-like dilations of the intracranial arterial wall; their hemorrhage commonly results in severe neurologic impairment and death. We report a secondExpand
  • 260
  • 13
  • PDF
High-Risk Ovarian Cancer Based on 126-Gene Expression Signature Is Uniquely Characterized by Downregulation of Antigen Presentation Pathway
Purpose: High-grade serous ovarian cancers are heterogeneous not only in terms of clinical outcome but also at the molecular level. Our aim was to establish a novel risk classification system basedExpand
  • 127
  • 11
  • PDF
Gene Expression Profile for Predicting Survival in Advanced-Stage Serous Ovarian Cancer Across Two Independent Datasets
Background Advanced-stage ovarian cancer patients are generally treated with platinum/taxane-based chemotherapy after primary debulking surgery. However, there is a wide range of outcomes forExpand
  • 118
  • 11
  • PDF
Gene expression profiling of advanced‐stage serous ovarian cancers distinguishes novel subclasses and implicates ZEB2 in tumor progression and prognosis
To elucidate the mechanisms of rapid progression of serous ovarian cancer, gene expression profiles from 43 ovarian cancer tissues comprising eight early stage and 35 advanced stage tissues wereExpand
  • 123
  • 10
Regulation of Geminin and Cdt1 expression by E2F transcription factors
Geminin and Cdt1 play an essential role in the initiation of DNA replication, by regulating the chromatin loading of the MCM complex. In this study, we showed that the transcription of human GemininExpand
  • 102
  • 10
Nucleotide diversity and haplotype structure of the human angiotensinogen gene in two populations.
Variation in the angiotensinogen gene, AGT, has been associated with variation in plasma angiotensinogen levels. In addition, the T235M polymorphism in the AGT product is associated with an increasedExpand
  • 128
  • 9
  • PDF
Next-generation sequencing: impact of exome sequencing in characterizing Mendelian disorders
Traditional approaches for gene mapping from candidate gene studies to positional cloning strategies have been applied for Mendelian disorders. Since 2005, next-generation sequencing (NGS)Expand
  • 193
  • 8