Flutamide

Known as: Propanamide, 2-Methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)-, Niftolid, Flutamide [Chemical/Ingredient] 
A toluidine derivative and a nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent… (More)
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
CONTEXT The few controlled trials performed so far indicate that the addition of metformin and/or flutamide to a hypocaloric diet… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Hyperandrogenism, hyperinsulinaemia and obesity play a key and coordinating roles in the pathogenesis of polycystic… (More)
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Highly Cited
2001
Highly Cited
2001
Male offspring exposed in utero to antiandrogens often display alterations in androgen-dependent developmental markers (e.g… (More)
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Highly Cited
2000
Highly Cited
2000
To compare objectively the efficacies of spironolactone (100 mg/day), flutamide (250 mg/day), and finasteride (5 mg/day) in the… (More)
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Highly Cited
2000
Highly Cited
2000
Polycystic ovarian syndrome (PCOS) is a complex disorder with multiple abnormalities, including hyperandrogenism, ovulatory… (More)
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Highly Cited
1999
Highly Cited
1999
Gestational and lactational exposure to di(n-butyl) phthalate (DBP) at >/=250 mg/kg/day disrupts male rat reproductive… (More)
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Highly Cited
1999
Highly Cited
1999
The role of androgen receptor (AR) mutations in androgen-independent prostate cancer (PCa) was determined by examining AR… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Combined androgen blockade for the treatment of metastatic prostate cancer consists of an antiandrogen drug plus… (More)
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Highly Cited
1993
Highly Cited
1993
PURPOSE To evaluate the effect of discontinuation of the antiandrogen, flutamide, in patients with metastatic prostate cancer who… (More)
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Highly Cited
1989
Highly Cited
1989
To test the hypothesis that maximal androgen blockade improves the effectiveness of the treatment of prostatic cancer, we… (More)
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