Finasteride

Known as: (5alpha,17beta)-N-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide, Finasterida, 4-Azaandrost-1-ene-17-carboxamide, N-(1,1-dimethylethyl)-3-oxo-, (5alpha,17beta)- 
A synthetic 4-azasteroid compound. Finasteride competitively binds to and inhibits steroid type II 5-alpha-reductase in the prostate gland, liver… (More)
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Finasteride taken for 7 years in the Prostate Cancer Prevention Trial (PCPT) reduced the risk of prostate cancer by 25%, but with… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND In the Prostate Cancer Prevention Trial (PCPT), men receiving finasteride had a 24.8% lower risk of prostate cancer… (More)
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Highly Cited
2005
Highly Cited
2005
Testosterone (T) therapy in older men with low serum T levels increases lean body mass and decreases fat mass. These changes… (More)
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Highly Cited
2004
Highly Cited
2004
Older men, particularly those with low serum testosterone (T) levels, might benefit from T therapy to improve bone mineral… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Androgens are involved in the development of prostate cancer. Finasteride, an inhibitor of 5alpha-reductase, inhibits… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Benign prostatic hyperplasia is commonly treated with alpha-adrenergic-receptor antagonists (alpha-blockers) or 5alpha… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Finasteride is known to improve urinary symptoms in men with benign prostatic hyperplasia, but the extent to which the… (More)
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Highly Cited
1996
Highly Cited
1996
OBJECTIVES Six randomized clinical trials have compared at least 1 year of 5 mg finasteride to placebo in the treatment of… (More)
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Highly Cited
1996
Highly Cited
1996
BACKGROUND Men with benign prostatic hyperplasia can be treated with alpha 1-adrenergic-antagonist drugs that relax prostatic… (More)
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Highly Cited
1992
Highly Cited
1992
BACKGROUND Benign prostatic hyperplasia is a progressive, androgen-dependent disease resulting in enlargement of the prostate… (More)
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