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Progesterone receptors: Form and function in brain
A prevalent missense substitution that modulates activity of prostatic steroid 5alpha-reductase.
One amino acid substitution is reported, V89L, which replaces valine at codon 89 with leucine, and it is common, panethnic, and reduces in vivo steroid 5alpha-reductase activity, which may explain the low risk for prostate cancer in this population.
Postmenopausal women with a history of irregular menses and elevated androgen measurements at high risk for worsening cardiovascular event-free survival: results from the National Institutes of…
Among postmenopausal women evaluated for suspected ischemia, clinical features of PCOS are associated with more angiographic coronary artery disease and worsening CV event-free survival.
Body size and serum levels of insulin and leptin in relation to the risk of benign prostatic hyperplasia.
Cytochrome P450c17alpha gene (CYP17) polymorphism is associated with serum estrogen and progesterone concentrations.
- H. Feigelson, L. Shames, M. Pike, G. Coetzee, F. Stanczyk, B. Henderson
- Biology, MedicineCancer research
- 15 February 1998
It is shown that CYP17 genotype is associated with serum hormone levels among 83 young, nulliparous women, and direct evidence of genetic control of serum hormones levels is provided.
Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women.
- T. Key, P. Appleby, S. Miller
- Medicine, BiologyJournal of the National Cancer Institute
- 20 August 2003
The results are compatible with the hypothesis that the increase in breast cancer risk with increasing BMI among postmenopausal women is largely the result of the associated increase in estrogens, particularly bioavailable estradiol.
Progestogens used in postmenopausal hormone therapy: differences in their pharmacological properties, intracellular actions, and clinical effects.
Differences in chemical structure, metabolism, pharmacokinetics, affinity, potency, and efficacy via steroid receptors, intracellular action, and biological and clinical effects confirm the absence of a class effect of progestogens.
Effect of exercise on serum estrogens in postmenopausal women: a 12-month randomized clinical trial.
It is concluded that a 12-month moderate-intensity exercise intervention in postmenopausal women resulted in significant decreases in serum estrogens, and the association between increased physical activity and reduced risk for post menopausal breast cancer may be partly explained by effects on serum estrogen.
Pregnancy, the postpartum, and steroid hormones: effects on cognition and mood