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A prevalent missense substitution that modulates activity of prostatic steroid 5alpha-reductase.
Prostate cancer is the most common serious cancer diagnosed in men in the United States. This disease is also characterized by a striking racial/ethnic variation in incidence: highest in… Expand
Body size and serum levels of insulin and leptin in relation to the risk of benign prostatic hyperplasia.
- Sara E Dahle, A. Chokkalingam, Y. Gao, J. Deng, F. Stanczyk, A. Hsing
- The Journal of urology
- 1 August 2002
PURPOSE Obesity has been implicated in the etiology of benign and malignant prostatic growth due to its influence on metabolic and endocrine changes. Because obesity is an important determinant of… Expand
Postmenopausal women with a history of irregular menses and elevated androgen measurements at high risk for worsening cardiovascular event-free survival: results from the National Institutes of…
- L. Shaw, C. N. Bairey Merz, +13 authors C. Pepine
- The Journal of clinical endocrinology and…
- 1 April 2008
BACKGROUND Women with polycystic ovary syndrome (PCOS) have a greater clustering of cardiac risk factors. However, the link between PCOS and cardiovascular (CV) disease is incompletely described. … Expand
Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease
- E. Rosario, L. Chang, E. Head, F. Stanczyk, C. Pike
- Psychology, Medicine
- Neurobiology of Aging
- 1 April 2011
We examined the relationships between normal aging, Alzheimer's disease (AD), and brain levels of sex steroid hormones in men and women. In postmortem brain tissue from neuropathologically normal,… Expand
Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women.
- T. Key, P. Appleby, +44 authors S. Miller
- Journal of the National Cancer Institute
- 20 August 2003
BACKGROUND Obesity is associated with increased breast cancer risk among postmenopausal women. We examined whether this association could be explained by the relationship of body mass index (BMI)… Expand
Cytochrome P450c17alpha gene (CYP17) polymorphism is associated with serum estrogen and progesterone concentrations.
- H. Feigelson, L. Shames, M. Pike, G. Coetzee, F. Stanczyk, B. Henderson
- Cancer research
- 15 February 1998
An increased level of serum estrogen is one marker of breast cancer risk. We have recently reported that increased risk of advanced breast cancer is associated with a common allele of the cytochrome… Expand
Progestogens used in postmenopausal hormone therapy: differences in their pharmacological properties, intracellular actions, and clinical effects.
The safety of progestogens as a class has come under increased scrutiny after the publication of data from the Women's Health Initiative trial, particularly with respect to breast cancer and… Expand
Effect of exercise on serum estrogens in postmenopausal women: a 12-month randomized clinical trial.
Elevated circulating estrogens and a sedentary lifestyle increase risk for breast cancer. The effect of exercise on circulating estrogens in sedentary postmenopausal women is unknown. The objective… Expand
Pregnancy, the postpartum, and steroid hormones: effects on cognition and mood
- J. Galen Buckwalter, F. Stanczyk, C. McCleary, B. W. Bluestein, T. Goodwin
- Medicine, Psychology
- 1 January 1999
The effects of pregnancy on cognition and mood were examined using a repeated-measures design. Nineteen women, average age 33, were tested with a comprehensive neuropsychological battery during their… Expand
Polymorphic markers in the SRD5A2 gene and prostate cancer risk: a population-based case-control study.
- A. Hsing, C. Chen, +9 authors J. Reichardt
- Biology, Medicine
- Cancer epidemiology, biomarkers & prevention : a…
- 1 October 2001
It has been suggested that the activity of the steroid 5alpha-reductase type II enzyme (encoded by the SRD5A2 gene) may be associated with prostate cancer risk and that population differences in this… Expand