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Fenclonine

Known as: para-Chlorophenylalanine, PCPA, DL-PCPA 
A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE… 
National Institutes of Health

Related topics

Related topics

13 relations

Narrower (1)

4-chlorophenylalanine ethyl ester

Broader (5)

Enzyme InhibitorsPhenylalanineSerotonin AgentsSerotonin Antagonists
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
0021-972X/05/$15.00/0 The Journal of Clinical Endocrinology & Metabolism 90(2):992–1000 Printed in U.S.A. Copyright © 2005 by The Endocrine Society doi: 10.1210/jc.2004-1429 Human Lymphocyte…
  • 2004
  • Corpus ID: 17820410
Highly Cited
1989
Highly Cited
1989
Condensation-sorting events in the rough endoplasmic reticulum of exocrine pancreatic cells
In guinea pig exocrine pancreatic cells intracisternal granules (ICGs) occur at a low frequency within the lumen of the RER. By… 
Highly Cited
1987
Highly Cited
1987
Hypothermia induced by the putative 5-HT1A agonists LY165163 and 8-OH-DPAT is not prevented by 5-HT depletion.
Highly Cited
1984
Highly Cited
1984
Anticonflict effect of the putative serotonin receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT).
Highly Cited
1982
Highly Cited
1982
Different synaptic location of mianserin and imipramine binding sites.
The high-affinity binding sites for mianserin and imipramine appear to be locate in different neurons of rat brain. Studies in… 
Highly Cited
1975
Highly Cited
1975
Hippocampal mediation of raphe lesion- and PCPA-induced hyperactivity in the rat
Highly Cited
1973
Highly Cited
1973
The role of the raphe nuclei in the regulation of ponto-geniculo-occipital wave activity.
Highly Cited
1972
Highly Cited
1972
Central monoamines and antinociceptive drug action.
Highly Cited
1970
Highly Cited
1970
Serotonin-Containing Neurons in Brain: Depression of Firing by Monoamine Oxidase Inhibitors
Monoamine oxidase inhibitors were administered to rats while the activities of single, serotonin-containing neurons of the… 
Highly Cited
1968
Highly Cited
1968
Alcohol Preference in the Rat: Reduction Following Depletion of Brain Serotonin
Preference for ethyl alcohol was significantly reduced or totally abolished in rats given orally p-chlorophenylalanine, a… 
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