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Fenclonine

Known as: para-Chlorophenylalanine, PCPA, DL-PCPA 
A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE… 
National Institutes of Health

Related topics

Related topics

13 relations

Narrower (1)

4-chlorophenylalanine ethyl ester

Broader (5)

Enzyme InhibitorsPhenylalanineSerotonin AgentsSerotonin Antagonists
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
0021-972X/05/$15.00/0 The Journal of Clinical Endocrinology & Metabolism 90(2):992–1000 Printed in U.S.A. Copyright © 2005 by The Endocrine Society doi: 10.1210/jc.2004-1429 Human Lymphocyte…
  • 2004
  • Corpus ID: 17820410
Highly Cited
2001
Highly Cited
2001
In Vivo Resetting of the Hamster Circadian Clock by 5-HT7 Receptors in the Suprachiasmatic Nucleus
Serotonin (5-HT) has been strongly implicated in the regulation of the mammalian circadian clock located in the suprachiasmatic… 
Highly Cited
1984
Highly Cited
1984
Anticonflict effect of the putative serotonin receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT).
Highly Cited
1982
Highly Cited
1982
Endogenous peptides and sleep in the rat: III the hypnogenic properties of vasoactive intestinal polypeptide
Highly Cited
1978
Highly Cited
1978
The role of a raphe serotonin system in the control of septal unit activity and hippocampal desynchronization
Highly Cited
1973
Highly Cited
1973
The role of the raphe nuclei in the regulation of ponto-geniculo-occipital wave activity.
Highly Cited
1972
Highly Cited
1972
Central monoamines and antinociceptive drug action.
Highly Cited
1971
Highly Cited
1971
Inhibitory effect of chlorpromazine on the syndrome of hyperactivity produced by l‐tryptophan or 5‐methoxy‐N,N‐dimethyltryptamine in rats treated with a monoamine oxidase inhibitor
1 The hyperactivity and hyperpyrexia produced by l‐tryptophan in rats treated with a monoamine oxidase inhibitor was inhibited by… 
Highly Cited
1968
Highly Cited
1968
The effect of para-chlorophenylalanine on the sleep of cats.
Highly Cited
1968
Highly Cited
1968
Alcohol Preference in the Rat: Reduction Following Depletion of Brain Serotonin
Preference for ethyl alcohol was significantly reduced or totally abolished in rats given orally p-chlorophenylalanine, a… 
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