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FRS2 protein, human

Known as: FGFR Substrate 2, FRS2A protein, human, FRS2alpha protein, human 
Encoded by human FRS2 Gene, 508-aa 56.8-kD FGFR Substrate 2 contains a myristylation sequence, a PTB domain, and 4 potential GRB2/SHP2-binding sites… 
National Institutes of Health

Related topics

Related topics

8 relations

Broader (2)

Adaptor Proteins, Signal TransducingMembrane Proteins
Adaptor Signaling Protein GeneFRS2 geneFRS2 wt AlleleSignal Transduction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2008
Review
2008
Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins
The FRS2 family of adaptor/scaffold proteins has two members, FRS2α and FRS2β. Both proteins contain N‐terminal myristylation… 
Highly Cited
2004
Highly Cited
2004
Model analysis of difference between EGF pathway and FGF pathway.
Highly Cited
2004
Highly Cited
2004
TrkB regulates neocortex formation through the Shc/PLCγ‐mediated control of neuronal migration
The generation of complex neuronal structures, such as the neocortex, requires accurate positioning of neurons and glia within… 
Highly Cited
2003
Highly Cited
2003
The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3
Receptor tyrosine kinases (RTKs) such as the fibroblast growth factor receptor (FGFR) and the epidermal growth factor receptor… 
Highly Cited
2002
Highly Cited
2002
FRS2α attenuates FGF receptor signaling by Grb2- mediated recruitment of the ubiquitin ligase Cbl
Attenuation of growth factor signaling is essential for the regulation of developmental processes and tissue homeostasis in most… 
Highly Cited
2001
Highly Cited
2001
Critical role for the docking-protein FRS2α in FGF receptor-mediated signal transduction pathways
The docking protein FRS2α has been implicated as a mediator of signaling via fibroblast growth factor receptors (FGFRs). We have… 
Highly Cited
2001
Highly Cited
2001
Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins
The docking protein FRS2 is a major downstream effector that links fibroblast growth factor (FGF) and nerve growth factor… 
Highly Cited
2001
Highly Cited
2001
Docking Protein FRS2 Links the Protein Tyrosine Kinase RET and Its Oncogenic Forms with the Mitogen-Activated Protein Kinase Signaling Cascade
ABSTRACT The receptor tyrosine kinase RET functions as the signal transducing receptor for the GDNF (for “glial cell-derived… 
Highly Cited
2000
Highly Cited
2000
FRS2 Proteins Recruit Intracellular Signaling Pathways by Binding to Diverse Targets on Fibroblast Growth Factor and Nerve Growth Factor Receptors
ABSTRACT The docking protein FRS2 was implicated in the transmission of extracellular signals from the fibroblast growth factor… 
Highly Cited
1998
Highly Cited
1998
Binding of Shp2 Tyrosine Phosphatase to FRS2 Is Essential for Fibroblast Growth Factor-Induced PC12 Cell Differentiation
ABSTRACT FRS2 is a lipid-anchored docking protein that plays an important role in linking fibroblast growth factor (FGF) and… 
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