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FRS2 protein, human

Known as: FGFR Substrate 2, FRS2A protein, human, FRS2alpha protein, human 
Encoded by human FRS2 Gene, 508-aa 56.8-kD FGFR Substrate 2 contains a myristylation sequence, a PTB domain, and 4 potential GRB2/SHP2-binding sites… 
National Institutes of Health

Related topics

Related topics

8 relations

Broader (2)

Adaptor Proteins, Signal TransducingMembrane Proteins
Adaptor Signaling Protein GeneFRS2 geneFRS2 wt AlleleSignal Transduction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
MicroRNA-613 attenuates the proliferation, migration and invasion of Wilms' tumor via targeting FRS2.
OBJECTIVE Wilms' tumor is the most common malignant tumor in children worldwide. Considering the poor therapeutic effect on Wilms… 
2016
2016
Fibroblast Growth Factor Receptor-Dependent and -Independent Paracrine Signaling by Sunitinib-Resistant Renal Cell Carcinoma
ABSTRACT Antiangiogenic therapies, such as sunitinib, have revolutionized renal cell carcinoma (RCC) treatment. However, a… 
2009
2009
An in vitro analysis of mechanical wounding-induced ligand-independent KGFR activation.
Highly Cited
2007
Highly Cited
2007
Keratinocyte Growth Factor Receptor Ligands Target the Receptor to Different Intracellular Pathways
The keratinocyte growth factor receptor (KGFR)/fibroblast growth factor receptor 2b is activated by high‐affinity‐specific… 
2006
2006
K644E/M FGFR3 mutants activate Erk1/2 from the endoplasmic reticulum through FRS2 alpha and PLC gamma-independent pathways.
Fibroblast growth factor receptors 3 (FGFR3) with K644M/E substitutions are associated to the severe skeletal dysplasias: severe… 
2005
2005
Tyrosine 769 of the keratinocyte growth factor receptor is required for receptor signaling but not endocytosis.
Highly Cited
2003
Highly Cited
2003
The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3
Receptor tyrosine kinases (RTKs) such as the fibroblast growth factor receptor (FGFR) and the epidermal growth factor receptor… 
2003
2003
Acidic substitution of the activation loop tyrosines in TrkA supports nerve growth factor-dependent, but not nerve growth factor-independent, differentiation and cell cycle arrest in the human…
TrkA is the receptor tyrosine kinase (RTK) for nerve growth factor (NGF) and stimulates NGF-dependent cell survival and… 
2001
2001
SNT-1/FRS2α physically interacts with Laloo and mediates mesoderm induction by fibroblast growth factor
Highly Cited
1996
Highly Cited
1996
Suc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2.
In Swiss 3T3 fibroblasts, basic fibroblast growth factor (bFGF) stimulates the unique tyrosine phosphorylation of a protein… 
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