FRS2 protein, human

Known as: FGFR Substrate 2, FRS2A protein, human, FRS2alpha protein, human 
Encoded by human FRS2 Gene, 508-aa 56.8-kD FGFR Substrate 2 contains a myristylation sequence, a PTB domain, and 4 potential GRB2/SHP2-binding sites… (More)
National Institutes of Health

Papers overview

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2013
2013
Fibroblast growth factor (FGF) receptor (FGFR) substrate 2 (FRS2) is an adaptor protein that plays a critical role in FGFR… (More)
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Highly Cited
2012
Highly Cited
2012
Lung cancer is the leading cause of cancer death for both men and women worldwide. Since most of the symptoms found for lung… (More)
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Review
2008
Review
2008
The FRS2 family of adaptor/scaffold proteins has two members, FRS2alpha and FRS2beta. Both proteins contain N-terminal… (More)
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2004
2004
The generation of complex neuronal structures, such as the neocortex, requires accurate positioning of neurons and glia within… (More)
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Highly Cited
2002
Highly Cited
2002
Sprouty (Spry) inhibits signalling by receptor tyrosine kinases; however, the molecular mechanism underlying this function has… (More)
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Highly Cited
2001
Highly Cited
2001
The docking protein FRS2 alpha has been implicated as a mediator of signaling via fibroblast growth factor receptors (FGFRs). We… (More)
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Highly Cited
2001
Highly Cited
2001
In PC12 cells, epidermal growth factor (EGF) transiently stimulates the mitogen-activated protein (MAP) kinases, ERK1 and ERK2… (More)
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Highly Cited
2000
Highly Cited
2000
The docking protein FRS2 was implicated in the transmission of extracellular signals from the fibroblast growth factor (FGF) or… (More)
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Highly Cited
1998
Highly Cited
1998
FRS2 is a lipid-anchored docking protein that plays an important role in linking fibroblast growth factor (FGF) and nerve growth… (More)
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Highly Cited
1997
Highly Cited
1997
Activation of the Ras/MAPK signaling cascade is essential for growth factor-induced cell proliferation and differentiation. In… (More)
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