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Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma.
Differentiation and survival of neuronal cell types requires the action of neurotrophic polypeptides such as nerve growth factor (NGF). In the central and peripheral nervous system and theExpand
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Targeted Peptide Measurements in Biology and Medicine: Best Practices for Mass Spectrometry-based Assay Development Using a Fit-for-Purpose Approach*
Adoption of targeted mass spectrometry (MS) approaches such as multiple reaction monitoring (MRM) to study biological and biomedical questions is well underway in the proteomics community. SuccessfulExpand
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N-terminal processing: the methionine aminopeptidase and N alpha-acetyl transferase families.
Removal of the initiator methionine and/or acetylation of the alpha-amino group are among the earliest possible chemical modifications that occur during protein synthesis in eukaryotes. These eventsExpand
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Eukaryotic methionyl aminopeptidases: two classes of cobalt-dependent enzymes.
Using partial amino acid sequence data derived from porcine methionyl aminopeptidase (MetAP; methionine aminopeptidase, peptidase M; EC 3.4.11.18), a full-length clone of the homologous human enzymeExpand
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NF-κB Signaling Promotes Both Cell Survival and Neurite Process Formation in Nerve Growth Factor-Stimulated PC12 Cells
Nerve growth factor binds to the TrkA and p75NTR (p75) and generates signals leading to neuronal cell survival, differentiation, and programmed cell death. Here we describe a series of experimentsExpand
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N-Terminal processing: the methionine aminopeptidase and Nα-acetyl transferase families
Abstract Removal of the initiator methionine and/or acetylation of the α-amino group are among the earliest possible chemical modifications that occur during protein synthesis in eukaryotes. TheseExpand
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Specificity of cotranslational amino-terminal processing of proteins in yeast.
Polypeptides synthesized in the cytoplasm of eukaryotes are generally initiated with methionine, but N-terminal methionine is absent from most mature proteins. Many proteins are also NExpand
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A review of the therapeutic uses of thrombin.
Thrombin is the product of the hemostatic response essential to the conversion of fibrinogen to fibrin. In addition, it is also responsible for the aggregation of blood platelets in the formation ofExpand
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Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture.
Bovine basic fibroblast growth factor (bFGF) is a potent mitogen isolated from bovine pituitary glands and brain. The addition of homogeneous bFGF to primary cultures of rat cerebral cortical neuronsExpand
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Amino acid sequence of Escherichia coli alkaline phosphatase.
The complete amino acid sequence of the Escherichia coli alkaline phosphatase subunit [orthophosphoric-monoester phosphohydrolase (alkaline optimum), EC 3.1.3.1, isozyme 3] has been determined. TheExpand
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