Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors

@article{Foehr2000DiscoidinDR,
  title={Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors},
  author={Erik D. Foehr and A Tatavos and Eriko Tanabe and Simona Raffioni and Sara E. Goetz and E Dimarco and Maria De Luca and Ralph A Bradshaw},
  journal={The FASEB Journal},
  year={2000},
  volume={14},
  pages={973 - 981}
}
The discoidin domain receptor (DDR1) is characterized by a discoidin I motif in the extracellular domain, an unusually long cytoplasmic juxtamembrane (JM) region, and a kinase domain that is 45% identical to that of the NGF receptor, TrkA. DDR1 also has a major splice form, which has a 37 amino acid insert in the JM region with a consensus Shc PTB site that is lacking in the shorter receptor. One class of ligands for the DDR receptors has recently been identified as being derived from the… 
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TLDR
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TLDR
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TLDR
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Discoidin domain receptor 1 isoform‐a (DDRla) promotes migration of leukocytes in three‐dimensional collagen lattices
TLDR
It is proposed that the interaction of DDR1a with collagen of the ECM results in a requisite intracellular signaling that enables leukocytes to migrate in a tissue microenvironment and participate in host defense.
Discoidin Domain Receptor 1 Tyrosine Kinase Has an Essential Role in Mammary Gland Development
TLDR
Results suggest that DDR1 is a key mediator of the stromal-epithelial interaction during ductal morphogenesis in the mammary gland.
Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor
TLDR
DDR1-IN-1 binds to DDR1 in the ‘DFG-out’ conformation and inhibits DDR1 autophosphorylation in cells at submicromolar concentrations with good selectivity as assessed against a panel of 451 kinases measured using the KinomeScan technology.
Discovery of a Potent and Selective DDR 1 Receptor Tyrosine Kinase Inhibitor
TLDR
A potent and selective DDR1 inhibitor, DDR1IN-1, is found and a mutation in the hinge region of DDR1, G707A, is identified that confers >20-fold resistance to the ability of DDR 1-IN-2 to inhibit DDR1 autophosphorylation and can be used to establish what pharmacology is DDR1-dependent.
Discoidin domain receptors: Micro insights into macro assemblies.
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