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FRS2 wt Allele

Known as: SNT-1, FRS2A, SNT 
Human FRS2 wild-type allele is located in the vicinity of 12q15 and is approximately 105 kb in length. This allele, which encodes fibroblast growth… 
National Institutes of Health

Related topics

Related topics

5 relations
12q15FRS2 protein, humanSignal Transductionprotein protein interaction

Broader (1)

FRS2 gene

Papers overview

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Highly Cited
2009
Highly Cited
2009
Prospective, Observational Study of Outcomes in Neonates With Severe Thrombocytopenia
OBJECTIVE: A cross-sectional, observational study of outcomes for neonates with severe neonatal thrombocytopenia (SNT; platelet… 
Highly Cited
2008
Highly Cited
2008
Increase in Reactive Oxygen Species and Activation of Akt Signaling Pathway in Neuropathic Pain
Neuropathic pain occurs as a result of peripheral or central nervous system injury. Its pathophysiology involves mainly a central… 
Highly Cited
2006
Highly Cited
2006
Neuropathic Pain Modifies Antioxidant Activity in Rat Spinal Cord
Oxidative stress is an important pathophysiological mechanism of many neurological diseases. Reactive oxygen and nitrogen species… 
2005
2005
The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse development.
The docking protein FRS2alpha is a major mediator of fibroblast growth factor (FGF) signaling. However, the physiological role of… 
Highly Cited
2004
Highly Cited
2004
Tyrosine phosphorylation sites on FRS2alpha responsible for Shp2 recruitment are critical for induction of lens and retina.
Early development of the lens and retina depends upon reciprocal inductive interactions between the embryonic surface ectoderm… 
Highly Cited
2004
Highly Cited
2004
The fixABCX Genes in Rhodospirillum rubrum Encode a Putative Membrane Complex Participating in Electron Transfer to Nitrogenase
ABSTRACT In our efforts to identify the components participating in electron transport to nitrogenase in Rhodospirillum rubrum… 
Highly Cited
2003
Highly Cited
2003
Peripheral nerve injury alters excitatory synaptic transmission in lamina II of the rat dorsal horn
Using the blind whole cell patch‐clamp recording technique, we investigated peripheral nerve injury‐induced changes in excitatory… 
Highly Cited
2003
Highly Cited
2003
The Thanatophoric Dysplasia Type II Mutation Hampers Complete Maturation of Fibroblast Growth Factor Receptor 3 (FGFR3), Which Activates Signal Transducer and Activator of Transcription 1 (STAT1…
The K650E substitution in the fibroblast growth factor receptor 3 (FGFR3) causes constitutive tyrosine kinase activity of the… 
Highly Cited
2000
Highly Cited
2000
FRS2 Proteins Recruit Intracellular Signaling Pathways by Binding to Diverse Targets on Fibroblast Growth Factor and Nerve Growth Factor Receptors
ABSTRACT The docking protein FRS2 was implicated in the transmission of extracellular signals from the fibroblast growth factor… 
Highly Cited
1998
Highly Cited
1998
Novel Recognition Motif on Fibroblast Growth Factor Receptor Mediates Direct Association and Activation of SNT Adapter Proteins*
Fibroblast growth factors (FGFs) stimulate tyrosine phosphorylation of a membrane-anchored adapter protein, FRS2/SNT-1, promoting… 
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