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Functional definition and characterization of acute traumatic coagulopathy
Objective:To identify an appropriate diagnostic tool for the early diagnosis of acute traumatic coagulopathy and validate this modality through prediction of transfusion requirements in traumaExpand
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Autologous bone marrow stem cells to treat acute myocardial infarction: a systematic review.
AIMS To provide systematic assessment of the safety and efficacy of autologous bone marrow-derived stem cell (BMSC) transplantation in acute myocardial infarction (AMI) based on clinical evidence. Expand
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The incidence and magnitude of fibrinolytic activation in trauma patients.
BACKGROUND Trauma is a global disease, with over 2.5 million deaths annually from hemorrhage and coagulopathy. Overt hyperfibrinolysis is rare in trauma, and is associated with massive fatalExpand
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Fibrinogen levels during trauma hemorrhage, response to replacement therapy, and association with patient outcomes.
BACKGROUND Low fibrinogen levels are known to occur in trauma. However, the extent of fibrinogen depletion during trauma hemorrhage, the response to replacement therapy and association with patientExpand
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A systematic review and economic evaluation of epoetin alpha, epoetin beta and darbepoetin alpha in anaemia associated with cancer, especially that attributable to cancer treatment.
OBJECTIVES To assess the effectiveness and cost-effectiveness of epoetin alpha, epoetin beta and darbepoetin alpha (referred to collectively in this report as epo) in anaemia associated with cancer,Expand
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Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations.
BACKGROUND Acute traumatic coagulopathy (ATC) is an impairment of hemostasis that occurs early after injury and is associated with a 4-fold higher mortality, increased transfusion requirements andExpand
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Age of transfused blood in critically ill adults.
BACKGROUND Fresh red cells may improve outcomes in critically ill patients by enhancing oxygen delivery while minimizing the risks of toxic effects from cellular changes and the accumulation ofExpand
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A no-prophylaxis platelet-transfusion strategy for hematologic cancers.
BACKGROUND The effectiveness of platelet transfusions to prevent bleeding in patients with hematologic cancers remains unclear. This trial assessed whether a policy of not giving prophylacticExpand
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Is fresh frozen plasma clinically effective? A systematic review of randomized controlled trials
Randomized controlled trials of good quality are a recognized means to robustly assess the efficacy of interventions in clinical practice. A systematic identification and appraisal of all randomizedExpand
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Stem cell treatment for acute myocardial infarction.
BACKGROUND Stem cell therapy offers a promising approach to the regeneration of damaged vascular and cardiac tissue after myocardial infarction (MI). This has resulted in multiple randomisedExpand
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