• Publications
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Receptor Specificity of the Fibroblast Growth Factor Family*
  • D. Ornitz, Jingsong Xu, +5 authors M. Goldfarb
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 21 June 1996
It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined. Expand
Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.
A family of cell surface-bound ligands exhibiting distinct, but overlapping, specificities for these EPH-related kinases was identified, suggesting that they require direct cell-to-cell contact to activate their receptors. Expand
Requirement of FGF-4 for postimplantation mouse development
Embryos homozygous for the null allele underwent uterine implantation and induced uterine decidualization but did not develop substantially thereafter, and growth and differentiation of the inner cell mass were rescued when null embryos were cultured in the presence of FGF-4 protein. Expand
Initiation of mammalian liver development from endoderm by fibroblast growth factors.
Different FGF signals appear to initiate distinct phases of liver development during mammalian organogenesis, and studies with FGFs and their specific inhibitors showed that FGF8 contributes to the morphogenetic outgrowth of the hepatic endoderm. Expand
The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases
The identification of ligands for Tyro 3 and Axl (alternatively, Ark or UFO), members of a previously orphan family of receptor-like tyrosine kinases, correspond to protein S, a protease regulator that is a potent anticoagulant, and Gas6, a protein related toprotein S but lacking any known function. Expand
An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors.
It is reported that the collagens serve as ligands for the previously orphan family of discoidin domain-containing receptor-like tyrosine kinases, and this finding seems likely to change prevailing views about the mechanisms by which cells perceive and respond to the extracellular matrix. Expand
Novel Recognition Motif on Fibroblast Growth Factor Receptor Mediates Direct Association and Activation of SNT Adapter Proteins*
These findings establish SNTs as direct protein links between FGFR-1 and multiple downstream pathways, distinct from previously described phosphotyrosine-binding domain recognition motifs, lacking both tyrosine and asparagine residues. Expand
Fibroblast growth factor homologous factors: evolution, structure, and function.
  • M. Goldfarb
  • Biology, Medicine
  • Cytokine & growth factor reviews
  • 1 April 2005
The sequences and structure of FHFs are reviewed, along with the still limited understanding of F HF function, to demonstrate the remarkable functional adaptability during evolution of the FGF gene family. Expand
Expression of the fibroblast growth factor-5 gene in the mouse embryo.
In situ hybridization methods are used to examine expression of the murine F gf-5 gene during embryogenesis to offer several hypotheses regarding the roles of FGF-5 in murine development. Expand
Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis.
In conclusion, FGF expression showed the greatest tissue-specific variability in abundance, with the highest levels detected in the developing limbs and tail, and Fgfa showed the least variable pattern of expression, with transcripts detected at roughly equivalent levels in almost all samples analyzed. Expand