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Receptor Specificity of the Fibroblast Growth Factor Family*
It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.
Requirement of FGF-4 for postimplantation mouse development
- B. Feldman, W. Poueymirou, VE Papaioannou, TM DeChiara, M. Goldfarb
- Biology, MedicineScience
- 13 January 1995
Embryos homozygous for the null allele underwent uterine implantation and induced uterine decidualization but did not develop substantially thereafter, and growth and differentiation of the inner cell mass were rescued when null embryos were cultured in the presence of FGF-4 protein.
Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.
A family of cell surface-bound ligands exhibiting distinct, but overlapping, specificities for these EPH-related kinases was identified, suggesting that they require direct cell-to-cell contact to activate their receptors.
Initiation of mammalian liver development from endoderm by fibroblast growth factors.
Different FGF signals appear to initiate distinct phases of liver development during mammalian organogenesis, and studies with FGFs and their specific inhibitors showed that FGF8 contributes to the morphogenetic outgrowth of the hepatic endoderm.
The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases
An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors.
Novel Recognition Motif on Fibroblast Growth Factor Receptor Mediates Direct Association and Activation of SNT Adapter Proteins*
These findings establish SNTs as direct protein links between FGFR-1 and multiple downstream pathways, distinct from previously described phosphotyrosine-binding domain recognition motifs, lacking both tyrosine and asparagine residues.
Expression of the fibroblast growth factor-5 gene in the mouse embryo.
In situ hybridization methods are used to examine expression of the murine F gf-5 gene during embryogenesis to offer several hypotheses regarding the roles of FGF-5 in murine development.
Fibroblast growth factor homologous factors: evolution, structure, and function.
- M. Goldfarb
- BiologyCytokine & growth factor reviews
- 1 April 2005
Fibroblast Growth Factor (FGF) Homologous Factors Share Structural but Not Functional Homology with FGFs*
It is shown that recombinant FHFs can bind heparin with high affinity like classical FGFs yet fail to activate any of the seven principal FGFRs, and it is demonstrated that FHFS bind IB2 directly, furthering the contention that F HFs and F GFs elicit their biological effects by binding to different protein partners.