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FPGS gene

Known as: FPGS, folylpolyglutamate synthase, Folylpolyglutamate Synthase Gene 
This gene plays a role in the metabolism of both folate and polyglutamate.
National Institutes of Health

Related topics

Related topics

3 relations
Folylpolyglutamate Synthase, MitochondrialFolylpolyglutamate synthasefolic acid metabolism

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Purine biosynthetic pathway genes and methotrexate response in rheumatoid arthritis patients among north Indians
Objective Inter-individual variations to methotrexate (MTX) response among rheumatoid arthritis (RA) patients have been… 
2008
2008
Folylpolyglutamate synthase and gamma-glutamyl hydrolase regulate leucovorin-enhanced 5-fluorouracil anticancer activity.
Review
1999
Review
1999
Mechanisms of methotrexate resistance in acute leukemia. Decreased transport and polyglutamylation.
Drug resistance limits the effectiveness of methotrexate (MTX) for the treatment of acute leukemia. An increased understanding of… 
1996
1996
Dietary folate and folylpolyglutamate synthetase activity in normal and neoplastic murine tissues and human tumor xenografts.
1996
1996
In vitro uptake, anabolism, and cellular retention of 1843U89 and other benzoquinazoline inhibitors of thymidylate synthase.
1843U89 is a potent inhibitor (Ki = 0.09 nM) of thymidylate synthase (TS; EC 2.1.1.45) that is in clinical trial for the… 
Review
1996
Review
1996
Section Review: Oncologic, Endocrine & Metabolic: The new generation of thymidylate synthase inhibitors in clinical study
In the last five years, six new antifolate drugs, all targeted towards thymidylate synthase (TS), have entered clinical studies… 
1995
1995
5-Arylthio-substituted 2-amino-4-oxo-6-methylpyrrolo[2,3-d]pyrimidine antifolates as thymidylate synthase inhibitors and antitumor agents.
Classical antifolate inhibitors of thymidylate synthase (TS) often require the reduced folate uptake system in order to exert… 
1994
1994
Benzo[f]quinazoline inhibitors of thymidylate synthase: methyleneamino-linked aroylglutamate derivatives.
Syntheses of several new inhibitors of thymidylate synthase (TS) structurally related to folic acid are described in which the… 
Highly Cited
1993
Highly Cited
1993
Decreased folylpolyglutamate synthetase expression: a novel mechanism of fluorouracil resistance.
HCT-8 cells become rapidly resistant to either 4-h (HCT-8/4hR) or 7-day (HCT-8/7dR) repeated exposures to fluorouracil (FUra… 
Highly Cited
1992
Highly Cited
1992
Experimental Transplantation With Principal Islets of Teleost Fish (Brockmann Bodies): Long-Term Function of Tilapia Islet Tissue in Diabetic Nude Mice
Certain teleost fish have macroscopically visible islets called BBs that are anatomically discrete. BBs were harvested from… 
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