FPGS gene

Known as: FPGS, folylpolyglutamate synthase, Folylpolyglutamate Synthase Gene 
This gene plays a role in the metabolism of both folate and polyglutamate.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1985-2017
024619852017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
We investigated the effect of single-nucleotide polymorphisms (SNPs) spanning 10 methotrexate (MTX) pathway genes, namely AMPD1… (More)
  • table 1
  • table 3
Is this relevant?
2012
2012
BACKGROUND Pemetrexed-based chemotherapy represents the standard of care in first-line treatment of advanced malignant pleural… (More)
Is this relevant?
2009
2009
Gene expression studies require appropriate normalization methods. One such method uses stably expressed reference genes. Since… (More)
  • table 1
  • table 2
  • table 3
  • table 4
  • table 5
Is this relevant?
2007
2007
We previously reported a lower risk of non-Hodgkin lymphoma (NHL) associated with high consumption of vitamin B6 and methionine… (More)
  • figure 1
  • table 1
  • table 2
  • table 3
  • table 3
Is this relevant?
2002
2002
Methotrexate (MTX) is one of the most widely used drugs for the treatment of childhood acute lymphoblastic leukemia (ALL… (More)
  • table 1
  • figure 2
  • table 2
  • figure 4
  • figure 5
Is this relevant?
1999
1999
Inefficient polyglutamylation is a mechanism of resistance to methotrexate (MTX) in childhood T-lineage acute lymphoblastic… (More)
Is this relevant?
1996
1996
Human cytosolic folylpolyglutamate synthetase (FPGS) was expressed in Escherichia coli and purified to homogeneity… (More)
Is this relevant?
1995
1995
The metabolism of 5,10-dideazatetrahydrofolate (DDATHF [lometrexol]) to polyglutamate derivatives by folylpoly-gamma-glutamate… (More)
Is this relevant?
1994
1994
Folylpolyglutamate synthetase (FPGS) is responsible for the metabolism of natural folates and a broad range of folate antagonists… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
1989
1989
N10-Propargyl-5,8-dideazafolic acid (CB3717) has proved to be an interesting recent addition to the spectrum of antifolate drugs… (More)
Is this relevant?