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FPGS gene

Known as: FPGS, folylpolyglutamate synthase, Folylpolyglutamate Synthase Gene 
This gene plays a role in the metabolism of both folate and polyglutamate.
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
OBJECTIVE The purpose of this study was to examine trends in postpartum glucose screening for women with gestational diabetes… Expand
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Highly Cited
2005
Highly Cited
2005
Aims/hypothesisIn type 2 diabetic patients we compared 9 months of combination therapy with insulin glargine and metformin with 9… Expand
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Highly Cited
2004
Highly Cited
2004
The ability of leukemia cells to accumulate methotrexate polyglutamate (MTXPG) is an important determinant of the antileukemic… Expand
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Highly Cited
2003
Highly Cited
2003
Pemetrexed (ALIMTA, MTA) is a novel thymidylate synthase (TS) inhibitor and has shown activity against colon cancer, mesothelioma… Expand
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2000
2000
MTA (LY231514) is an antifolate that targets multiple folate-dependent enzymes. In this report, MTA transport was characterized… Expand
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2000
2000
Gemcitabine (2'-2'-difluorodeoxycytidine; dFdC) is a deoxycytidine analogue which is effective against solid tumours, including… Expand
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Review
1997
Review
1997
Understanding the relationship between chemical structure and biological properties of folate analogs, particularly their… Expand
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Review
1995
Review
1995
The enzyme, thymidylate synthase (TS) is considered an important target for the development of new anticancer agents. Moreover… Expand
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1993
1993
The effect of folylpoly-gamma-glutamate synthetase (FPGS) levels on folate accumulation was investigated in Chinese hamster ovary… Expand
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Highly Cited
1991
Highly Cited
1991
N-(5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N- methylamino]-2-thenoyl)-L-glutamic acid (ICI D1694) is a water… Expand
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