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Folylpolyglutamate synthase

Known as: folylpoly-gamma-glutamate synthetase, folylpolyglutamate synthetase, tetrahydrofolylpolyglutamate synthase 
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Pemetrexed (MTA) is a multitargeted antifolate with promising clinical activity in lung cancer. We exposed the small cell lung… 
Highly Cited
2001
Highly Cited
2001
Tetrahydrofolate coenzymes involved in one-carbon (C1) metabolism are polyglutamylated. In organisms that synthesize… 
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Highly Cited
2001
Highly Cited
2001
Folates have been co-administered with some antifolates to diminish host toxicity; however, the extent to which this will reduce… 
2001
2001
Enzymes MurD, MurE, MurF, folylpolyglutamate synthetase and cyanophycin synthetase, which belong to the Mur synthetase… 
Highly Cited
2000
Highly Cited
2000
UDP-N-acetylmuramoyl-l-alanine:d-glutamate (MurD) ligase catalyses the addition of d-glutamate to the nucleotide precursor UDP-N… 
Highly Cited
1999
Highly Cited
1999
Inefficient polyglutamylation is a mechanism of resistance to methotrexate (MTX) in childhood T-lineage acute lymphoblastic… 
Highly Cited
1998
Highly Cited
1998
Folylpolyglutamate synthetase, which is responsible for the addition of a polyglutamate tail to folate and folate derivatives, is… 
Highly Cited
1996
Highly Cited
1996
Human cytosolic folylpolyglutamate synthetase (FPGS) was expressed in Escherichia coli and purified to homogeneity… 
Highly Cited
1995
Highly Cited
1995
The transport properties and growth-inhibitory potential of 37 classic and novel antifolate compounds have been tested in vitro… 
Review
1985
Review
1985
The studies discussed in this review support the view that biochemical and clinical symptoms common to both folate and vitamin…