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Folylpolyglutamate synthase

Known as: folylpoly-gamma-glutamate synthetase, folylpolyglutamate synthetase, tetrahydrofolylpolyglutamate synthase 
National Institutes of Health

Related topics

Related topics

3 relations
FPGS gene

Narrower (1)

MET7 protein, S cerevisiae

Broader (1)

peptide synthase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Significance of thymidylate synthase for resistance to pemetrexed in lung cancer
Pemetrexed (MTA) is a multitargeted antifolate with promising clinical activity in lung cancer. We exposed the small cell lung… 
Highly Cited
2001
Highly Cited
2001
Tetrahydrofolate biosynthesis in plants: Molecular and functional characterization of dihydrofolate synthetase and three isoforms of folylpolyglutamate synthetase in Arabidopsis thaliana
Tetrahydrofolate coenzymes involved in one-carbon (C1) metabolism are polyglutamylated. In organisms that synthesize… 
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Highly Cited
2001
Highly Cited
2001
Marked suppression of the activity of some, but not all, antifolate compounds by augmentation of folate cofactor pools within tumor cells.
Folates have been co-administered with some antifolates to diminish host toxicity; however, the extent to which this will reduce… 
2001
2001
Evidence of a functional requirement for a carbamoylated lysine residue in MurD, MurE and MurF synthetases as established by chemical rescue experiments.
Enzymes MurD, MurE, MurF, folylpolyglutamate synthetase and cyanophycin synthetase, which belong to the Mur synthetase… 
Highly Cited
2000
Highly Cited
2000
"Open" structures of MurD: domain movements and structural similarities with folylpolyglutamate synthetase.
UDP-N-acetylmuramoyl-l-alanine:d-glutamate (MurD) ligase catalyses the addition of d-glutamate to the nucleotide precursor UDP-N… 
Highly Cited
1999
Highly Cited
1999
Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia.
Inefficient polyglutamylation is a mechanism of resistance to methotrexate (MTX) in childhood T-lineage acute lymphoblastic… 
Highly Cited
1998
Highly Cited
1998
Structural homologies with ATP- and folate-binding enzymes in the crystal structure of folylpolyglutamate synthetase.
Folylpolyglutamate synthetase, which is responsible for the addition of a polyglutamate tail to folate and folate derivatives, is… 
Highly Cited
1996
Highly Cited
1996
Purification and Properties of Human Cytosolic Folylpoly-γ-glutamate Synthetase and Organization, Localization, and Differential Splicing of Its Gene*
Human cytosolic folylpolyglutamate synthetase (FPGS) was expressed in Escherichia coli and purified to homogeneity… 
Highly Cited
1995
Highly Cited
1995
Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity.
The transport properties and growth-inhibitory potential of 37 classic and novel antifolate compounds have been tested in vitro… 
Review
1985
Review
1985
Vitamin B12-folate interrelationships.
The studies discussed in this review support the view that biochemical and clinical symptoms common to both folate and vitamin… 
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