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Folylpolyglutamate synthase
Known as:
folylpoly-gamma-glutamate synthetase
, folylpolyglutamate synthetase
, tetrahydrofolylpolyglutamate synthase
National Institutes of Health
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Related topics
Related topics
3 relations
FPGS gene
Narrower (1)
MET7 protein, S cerevisiae
Broader (1)
peptide synthase
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Significance of thymidylate synthase for resistance to pemetrexed in lung cancer
H. Ozasa
,
T. Oguri
,
+4 authors
R. Ueda
Cancer Science
2010
Corpus ID: 21769020
Pemetrexed (MTA) is a multitargeted antifolate with promising clinical activity in lung cancer. We exposed the small cell lung…
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2001
2001
Evidence of a functional requirement for a carbamoylated lysine residue in MurD, MurE and MurF synthetases as established by chemical rescue experiments.
S. Dementin
,
A. Bouhss
,
+5 authors
D. Blanot
European Journal of Biochemistry
2001
Corpus ID: 23785309
Enzymes MurD, MurE, MurF, folylpolyglutamate synthetase and cyanophycin synthetase, which belong to the Mur synthetase…
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Highly Cited
2001
Highly Cited
2001
Tetrahydrofolate biosynthesis in plants: Molecular and functional characterization of dihydrofolate synthetase and three isoforms of folylpolyglutamate synthetase in Arabidopsis thaliana
S. Ravanel
,
H. Cherest
,
+4 authors
F. Rébeillé
Proceedings of the National Academy of Sciences…
2001
Corpus ID: 5614262
Tetrahydrofolate coenzymes involved in one-carbon (C1) metabolism are polyglutamylated. In organisms that synthesize…
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Highly Cited
2001
Highly Cited
2001
Marked suppression of the activity of some, but not all, antifolate compounds by augmentation of folate cofactor pools within tumor cells.
R. Zhao
,
F. Gao
,
I. Goldman
Biochemical Pharmacology
2001
Corpus ID: 22993533
Highly Cited
2000
Highly Cited
2000
"Open" structures of MurD: domain movements and structural similarities with folylpolyglutamate synthetase.
J. Bertrand
,
E. Fanchon
,
+5 authors
O. Dideberg
Journal of Molecular Biology
2000
Corpus ID: 32343126
UDP-N-acetylmuramoyl-l-alanine:d-glutamate (MurD) ligase catalyses the addition of d-glutamate to the nucleotide precursor UDP-N…
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Highly Cited
1999
Highly Cited
1999
Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia.
M. Rots
,
R. Pieters
,
+7 authors
G. Jansen
Blood
1999
Corpus ID: 40961272
Inefficient polyglutamylation is a mechanism of resistance to methotrexate (MTX) in childhood T-lineage acute lymphoblastic…
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Highly Cited
1998
Highly Cited
1998
Structural homologies with ATP- and folate-binding enzymes in the crystal structure of folylpolyglutamate synthetase.
X. Sun
,
A. Bognar
,
E. Baker
,
C. Smith
Proceedings of the National Academy of Sciences…
1998
Corpus ID: 20318621
Folylpolyglutamate synthetase, which is responsible for the addition of a polyglutamate tail to folate and folate derivatives, is…
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Highly Cited
1996
Highly Cited
1996
Purification and Properties of Human Cytosolic Folylpoly-γ-glutamate Synthetase and Organization, Localization, and Differential Splicing of Its Gene*
Linda Chen
,
H. Qi
,
J. Korenberg
,
T. Garrow
,
Yun-Jung Choi
,
B. Shane
Journal of Biological Chemistry
1996
Corpus ID: 45356833
Human cytosolic folylpolyglutamate synthetase (FPGS) was expressed in Escherichia coli and purified to homogeneity…
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Highly Cited
1995
Highly Cited
1995
Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity.
G. Westerhof
,
J. Schornagel
,
+7 authors
H. Pinedo
Molecular Pharmacology
1995
Corpus ID: 2582928
The transport properties and growth-inhibitory potential of 37 classic and novel antifolate compounds have been tested in vitro…
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Review
1985
Review
1985
Vitamin B12-folate interrelationships.
B. Shane
,
E. Stokstad
Annual review of nutrition
1985
Corpus ID: 13294786
The studies discussed in this review support the view that biochemical and clinical symptoms common to both folate and vitamin…
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