Folylpolyglutamate synthase

Known as: folylpoly-gamma-glutamate synthetase, folylpolyglutamate synthetase, tetrahydrofolylpolyglutamate synthase 
 
National Institutes of Health

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3 relations
FPGS gene

Narrower (1)

MET7 protein, S cerevisiae

Broader (1)

peptide synthase

Papers overview

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2015
2015
The maize brown midrib4 (bm4) gene encodes a functional folylpolyglutamate synthase
Mutations in the brown midrib4 (bm4) gene affect the accumulation and composition of lignin in maize. Fine-mapping analysis of… (More)
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2008
2008
Structures of Mycobacterium tuberculosis folylpolyglutamate synthase complexed with ADP and AMPPCP
Folate derivatives are essential vitamins for cell growth and replication, primarily because of their central role in reactions… (More)
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2001
2001
Tetrahydrofolate biosynthesis in plants: molecular and functional characterization of dihydrofolate synthetase and three isoforms of folylpolyglutamate synthetase in Arabidopsis thaliana.
Tetrahydrofolate coenzymes involved in one-carbon (C1) metabolism are polyglutamylated. In organisms that synthesize… (More)
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2000
2000
"Open" structures of MurD: domain movements and structural similarities with folylpolyglutamate synthetase.
UDP-N-acetylmuramoyl-l-alanine:d-glutamate (MurD) ligase catalyses the addition of d-glutamate to the nucleotide precursor UDP-N… (More)
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Highly Cited
1999
Highly Cited
1999
Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia.
Inefficient polyglutamylation is a mechanism of resistance to methotrexate (MTX) in childhood T-lineage acute lymphoblastic… (More)
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1997
1997
gamma-Glutamyl hydrolase and folylpolyglutamate synthetase activities predict polyglutamylation of methotrexate in acute leukemias.
Decreased methotrexate (MTX) long-chain polyglutamate formation is associated with MTX resistance whereas high levels of MTX… (More)
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1997
1997
Disparate affinities of antifolates for folylpolyglutamate synthetase from human leukemia cells.
Previous work showed that acute myelocytic leukemia blasts accumulate less long chain polyglutamates of methotrexate (MTX) than… (More)
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Highly Cited
1995
Highly Cited
1995
Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity.
The transport properties and growth-inhibitory potential of 37 classic and novel antifolate compounds have been tested in vitro… (More)
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1993
1993
Purification and general properties of human folylpolyglutamate synthetase.
 
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Highly Cited
1989
Highly Cited
1989
A new folate antimetabolite, 5,10-dideaza-5,6,7,8-tetrahydrofolate is a potent inhibitor of de novo purine synthesis.
5,10-Dideazatetrahydrofolate (DDATHF) is a new antimetabolite designed as an inhibitor of folate metabolism at sites other than… (More)
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