Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Folylpolyglutamate synthase

Known as: folylpoly-gamma-glutamate synthetase, folylpolyglutamate synthetase, tetrahydrofolylpolyglutamate synthase 
 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Pemetrexed (MTA) is a multitargeted antifolate with promising clinical activity in lung cancer. We exposed the small cell lung… Expand
Is this relevant?
2003
2003
We identified a mutation in Arabidopsis that resulted in defective embryos, and we designated this mutation globular arrest1… Expand
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Tetrahydrofolate coenzymes involved in one-carbon (C1) metabolism are polyglutamylated. In organisms that synthesize… Expand
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • figure 4
Is this relevant?
2001
2001
Enzymes MurD, MurE, MurF, folylpolyglutamate synthetase and cyanophycin synthetase, which belong to the Mur synthetase… Expand
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Folates have been co-administered with some antifolates to diminish host toxicity; however, the extent to which this will reduce… Expand
Is this relevant?
Highly Cited
2000
Highly Cited
2000
UDP-N-acetylmuramoyl-l-alanine:d-glutamate (MurD) ligase catalyses the addition of d-glutamate to the nucleotide precursor UDP-N… Expand
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Inefficient polyglutamylation is a mechanism of resistance to methotrexate (MTX) in childhood T-lineage acute lymphoblastic… Expand
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Folylpolyglutamate synthetase, which is responsible for the addition of a polyglutamate tail to folate and folate derivatives, is… Expand
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Human cytosolic folylpolyglutamate synthetase (FPGS) was expressed in Escherichia coli and purified to homogeneity… Expand
Is this relevant?
Highly Cited
1995
Highly Cited
1995
The transport properties and growth-inhibitory potential of 37 classic and novel antifolate compounds have been tested in vitro… Expand
Is this relevant?