Folylpolyglutamate synthase

Pemetrexed (MTA) is a multitargeted antifolate with promising clinical activity in lung cancer. We exposed the small cell lung… Expand

We identified a mutation in Arabidopsis that resulted in defective embryos, and we designated this mutation globular arrest1… Expand

Tetrahydrofolate coenzymes involved in one-carbon (C1) metabolism are polyglutamylated. In organisms that synthesize… Expand

Enzymes MurD, MurE, MurF, folylpolyglutamate synthetase and cyanophycin synthetase, which belong to the Mur synthetase… Expand

Folates have been co-administered with some antifolates to diminish host toxicity; however, the extent to which this will reduce… Expand

UDP-N-acetylmuramoyl-l-alanine:d-glutamate (MurD) ligase catalyses the addition of d-glutamate to the nucleotide precursor UDP-N… Expand

Inefficient polyglutamylation is a mechanism of resistance to methotrexate (MTX) in childhood T-lineage acute lymphoblastic… Expand

Folylpolyglutamate synthetase, which is responsible for the addition of a polyglutamate tail to folate and folate derivatives, is… Expand

Human cytosolic folylpolyglutamate synthetase (FPGS) was expressed in Escherichia coli and purified to homogeneity… Expand

The transport properties and growth-inhibitory potential of 37 classic and novel antifolate compounds have been tested in vitro… Expand