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peptide synthase

Known as: Synthases, Peptide, Acid-Amino-Acid Ligases, Acid Amino Acid Ligases 
Ligases that catalyze the joining of adjacent AMINO ACIDS by the formation of carbon-nitrogen bonds between their carboxylic acid groups and amine… 
National Institutes of Health

Related topics

Related topics

48 relations

Narrower (41)

2,3-Dihydroxybenzoate serine ligase4-dimethylamino-L-phenylalanine thioester N-methylating enzymeAtg3 protein, ratDihydrofolate synthase

Broader (1)

Carbon-Nitrogen Ligases
In BloodProcess of secretionacid-D-amino acid ligase activityantagonists & inhibitors

Papers overview

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Highly Cited
2007
Highly Cited
2007
Structural analysis of a non-ribosomal halogenated cyclic peptide and its putative operon from Microcystis: implications for evolution of cyanopeptolins.
The structure of the major peptide produced by Microcystis cf. wesenbergii NIVA-CYA 172/5, the halogenated heptapeptide… 
Highly Cited
2005
Highly Cited
2005
The Biosynthesis of Vancomycin‐Type Glycopeptide Antibiotics—A Model for Oxidative Side‐Chain Cross‐Linking by Oxygenases Coupled to the Action of Peptide Synthetases
Vancomycin (Scheme 1) and teicoplanin are “last resort” antibiotics for the treatment of severe infections with enterococci and… 
Highly Cited
2003
Highly Cited
2003
Aminoacyl Adenylate Substrate Analogues for the Inhibition of Adenylation Domains of Nonribosomal Peptide Synthetases
Microorganisms are well-known producers of bioactive peptides, which have become important elements of modern medicine. The… 
2001
2001
A physical map of the syringomycin and syringopeptin gene clusters localized to an approximately 145-kb DNA region of Pseudomonas syringae pv. syringae strain B301D.
Genetic and phenotypic mapping of an approximately 145-kb DraI fragment of Pseudomonas syringae pv. syringae strain B301D… 
Highly Cited
2000
Highly Cited
2000
Genes encoding synthetases of cyclic depsipeptides, anabaenopeptilides, in Anabaena strain 90
Anabaena strain 90 produces three hepatotoxic heptapeptides (microcystins), two seven‐residue depsipeptides called… 
Review
1997
Review
1997
Biosynthetic systems for nonribosomal peptide antibiotic assembly.
Review
1996
Review
1996
Engineered biosynthesis of peptide antibiotics.
Highly Cited
1996
Highly Cited
1996
Two multifunctional peptide synthetases and an O-methyltransferase are involved in the biosynthesis of the DNA-binding antibiotic and antitumour agent saframycin Mx1 from Myxococcus xanthus.
Saframycin Mx1 is a DNA-binding antibiotic and antitumour agent produced by Myxococcus xanthus. It is a heterocyclic quinone… 
1994
1994
ATP binding in peptide synthetases: determination of contact sites of the adenine moiety by photoaffinity labeling of tyrocidine synthetase 1 with 2-azidoadenosine triphosphate.
Characterization of the nucleotide binding domain in peptide synthetases was approached by photoaffinity labeling of tyrocidine… 
Highly Cited
1993
Highly Cited
1993
Nucleotide sequence of 5' portion of srfA that contains the region required for competence establishment in Bacillus subtilus
The nucleotide sequence of the 20,535 base pairs of the 5' end of the srfA operon, containing the region required for competence… 
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