Skip to search formSkip to main contentSkip to account menu

peptide synthase

Known as: Synthases, Peptide, Acid-Amino-Acid Ligases, Acid Amino Acid Ligases 
Ligases that catalyze the joining of adjacent AMINO ACIDS by the formation of carbon-nitrogen bonds between their carboxylic acid groups and amine… 
National Institutes of Health

Related topics

Related topics

48 relations

Narrower (41)

2,3-Dihydroxybenzoate serine ligase4-dimethylamino-L-phenylalanine thioester N-methylating enzymeAtg3 protein, ratDihydrofolate synthase

Broader (1)

Carbon-Nitrogen Ligases
In BloodProcess of secretionacid-D-amino acid ligase activityantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Conformational Switches Modulate Protein Interactions in Peptide Antibiotic Synthetases
Protein dynamics plays an important role in protein function. Many functionally important motions occur on the microsecond and… 
Highly Cited
2006
Highly Cited
2006
Structure of the EntB multidomain nonribosomal peptide synthetase and functional analysis of its interaction with the EntE adenylation domain.
Highly Cited
2005
Highly Cited
2005
The Biosynthesis of Vancomycin‐Type Glycopeptide Antibiotics—A Model for Oxidative Side‐Chain Cross‐Linking by Oxygenases Coupled to the Action of Peptide Synthetases
Vancomycin (Scheme 1) and teicoplanin are “last resort” antibiotics for the treatment of severe infections with enterococci and… 
Highly Cited
2001
Highly Cited
2001
Elimination of ergovaline from a grass–Neotyphodium endophyte symbiosis by genetic modification of the endophyte
The fungal endophytes Neotyphodium lolii and Neotyphodium sp. Lp1 from perennial ryegrass (Lolium perenne), and related… 
Highly Cited
2000
Highly Cited
2000
Genes encoding synthetases of cyclic depsipeptides, anabaenopeptilides, in Anabaena strain 90
Anabaena strain 90 produces three hepatotoxic heptapeptides (microcystins), two seven‐residue depsipeptides called… 
Highly Cited
1998
Highly Cited
1998
Genetic evidence for a role of thioesterase domains, integrated in or associated with peptide synthetases, in non-ribosomal peptide biosynthesis in Bacillus subtilis
Abstract Next to almost all prokaryotic operons encoding peptide synthetases, which are involved in the nonribosomal synthesis of… 
Highly Cited
1997
Highly Cited
1997
Engineering of Peptide Synthetases
Peptide synthetases are large enzymatic complexes that catalyze the synthesis of biologically active peptides in microorganisms… 
Highly Cited
1997
Highly Cited
1997
The pipecolate-incorporating enzyme for the biosynthesis of the immunosuppressant rapamycin--nucleotide sequence analysis, disruption and heterologous expression of rapP from Streptomyces…
An open reading frame (rapP) encoding the putative pipecolate-incorporating enzyme (PIE) has been identified in the gene cluster… 
Highly Cited
1995
Highly Cited
1995
Multienzymatic non ribosomal peptide biosynthesis: identification of the functional domains catalysing peptide elongation and epimerisation.
Peptide synthetases are multienzymatic complexes that synthesize bioactive peptides molecules by the thiotemplate mechanism… 
Highly Cited
1991
Highly Cited
1991
Delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Aspergillus nidulans. Molecular characterization of the acvA gene encoding the first enzyme of the penicillin biosynthetic pathway.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)